CHIRWERE CHE ALZHEIMER: KO NEURON PLASTICITY INOFANIRA KUTI AXONAL NEUROFIBRILLARY DEGENERATION?
New England Journal yeMishonga, Vol. 313, mapeji 388-389, 1985
CHIRWERE CHE ALZHEIMER: KO NEURON PLASTICITY INOFANIRA KUTI AXONAL NEUROFIBRILLARY DEGENERATION?
KuMupepeti: Gajdusek anofungidzira kuti kukanganisa kweurofilaments ndiyo hwaro hwezvirwere zvakati wandei (Kurume 14 nyaya). 1 Kuti atsanangure kuti nei mamwe ma neuron ari muuropi achibatwa uye kwete mamwe, anoratidza kuti masero ane miti mikuru yemaaxonal, nekuda kwekuda kwavo kukuru kwekutakura axonal, inonyanya kukuvadzwa nekukuvara kweaxoskeletal. Gajduseks's hypothesis inoyevedza asi inotadza kuzvidavirira pamusoro pekuona kuti hombe otor neurons inobatwa zvishoma muchirwere cheAlzheimer.
Isu tinokurudzira kuti cell plasticity pamwe nehukuru hwemuti weaxonal inogona kuisa zvinodiwa pakutakura axonal. Iyo plasticity yemasero emagetsi yave yakabatana nemhando dzakasiyana dzetrophic factor,2 mamwe acho anosanganisira axonal transport. Muenzaniso wakakodzera ndeyekumera kunoonekwa mu septal norepinephrine terminals,3 zvichida inoperekedzwa nekuwanda kukuru kwemaurofilaments matsva.
MaNeuroni anoratidza yakakwira dhigirii repurasitiki pamwe anoumba iyo substrate ye chiyeuchidzo nekudzidza; vose vari kukanganiswa nechirwere cheAlzheimer. Norepinephrine nzira dzakabatanidzwa nekudzidza kwakabatana nemubairo,4 uye norephinephrine masero e locus ceruleus anoparadzwa mune dzimwe nguva. Chirwere cheAlzheimer.5 Alzheimer degeneration inokuvadzawo nzvimbo yekwakabva masero e serotonin mu midbrain raphe,6 uye serotonin yakarongedzerwa semurevereri we classic conditioning.7 Acetylcholine pathways projecting kubva nucleus basalis ye Meynert kusvika kune cortex inogona kuva nebasa. ye latchkey mune yakaoma memory kuchengetedza nekudzorera,8.9 uye sezvinonyatsozivikanwa, chirwere cheAlzheimer chinosanganiswa nekurasikirwa kwemasero aya pamwe chete nema enzymes. 10 iyo yose inobata basa guru mukuyeuka.11 Uyezve, kuparara kweurofibrillary kunoitika zvakasarudzwa mumaneuroni ane maaxon anobatanidza hippocampus ne entorhinal cortex.12 Sezvo neurons kubva kune rimwe nerimwe remapoka aya anoumba hukama hunobatanidza ne encoding yemashoko,13 inoda a yakakwira dhigirii repurasitiki, kuderera kwavo kunotsigira fungidziro yekuti masero anoratidza mapurasitiki akawanda anowanzo kanganisa neurofibrillary.
Kuvhiringidzwa kweanononoka axonal-transport mechanism mumaneuroni ane dhigirii yakakwira yepurasitiki inogona kukonzeresa kusashanda zvakanaka kwendangariro, chiratidzo chikuru che dementia zvisinei nechikonzero. Iyi axonal-filament dysfunction inogona kupa micropathological hwaro hweiyo yakambomisikidzwa link pakati pe microtubular diathesis neAlzheimer-type. dementia 15,16 uye sunga pamwechete chikamu chidiki chezvirwere zvedementia.
J. Wesson Ashford, MD, Ph.D.
Lissy Jarvik, MD, Ph.D.
UCLA Neuropsychiatric Institute
Los Angeles, CA 90024