Kufambira mberi mukuongorora midziyo yechirwere cheAlzheimer
- PMID: 31942517
- PMCID: PMC6880670
- DOI: 10.1002 / AGM2.12069
ngovepo
Pahwaro hwayo hwakakosha, Chirwere cheAlzheimer (AD) inzira ye pathological inokanganisa neuroplasticity, inotungamira kune chaiyo kukanganisa kwe episodic memory. Ongororo iyi ichapa chikonzero chekufona kuti vatarise kuongororwa kwekutanga kwechirwere cheAlzheimer, kuongorora zvishandiso zviripo zvekuziva zvekuonekwa kwechirwere cheAlzheimer, uye kutarisa kusimudzira kweMemTrax. ndangariro bvunzo online, iyo inopa nzira itsva yekuona kuratidzwa kwekutanga uye kufambira mberi kwedementia inobatanidza nechirwere cheAlzheimer. MemTrax inoongorora mametrics anoratidza mhedzisiro yemaitiro neuroplastic pakudzidza, ndangariro, uye cognition, izvo zvinokanganiswa nezera uye. Chirwere cheAlzheimer, kunyanya episodic memory function, izvo zvisingakwanisi kuyerwa iye zvino nemazvo zvakakwana kuti zvishandiswe zvine musoro. Kumwe kusimudzira kweMemTrax kungave kwekukosha kukuru kune kuonekwa kwekutanga kwechirwere cheAlzheimer uye yaizopa tsigiro yekuyedzwa kwekupindira kwekutanga.
NHANGANYAYA
Chirwere cheAlzheimer (AD) chirwere chinonyengera, chinofambira mberi, uye chisingadzoreki cheurodegenerative icho pari zvino chinofungidzirwa kuti chinotanga kukanganisa uropi makore makumi mashanu chirwere chisati chaonekwa (Braak stage V). Sokutungamirira chikonzero chedementia, inoverengera 60-70% yezviitiko zvose zvedementia, AD inobata vanenge 5.7 vokuAmerica uye vanhu vanopfuura mamiriyoni 30 pasi rose. Maererano ne "Nyika Alzheimer Report 2018, ”kune nyaya nyowani yedementia yakagadziridzwa masekonzi ega ega e3 pasirese uye 66% yevarwere vedementia vanogara munyika dzine mari yakaderera uye yepakati.
Chirwere cheAlzheimer ndicho chega chirwere chikuru icho parizvino chisina nzira dzinoshanda dzekurapa, kudzosera kumashure, kusunga, kana kutoderedza kufambira mberi kwechirwere kana zviratidzo zvatanga. Pasinei nekufambira mberi kwakaitwa mukati kunzwisisa iyo inodzika pathophysiology yechirwere cheAlzheimer, kurapwa kwechirwere ichi kwafambira mberi zvishoma kubva apo AD yakatanga kutaurwa naAlois Alzheimer muna 1906. Parizvino mishonga mishanu chete kubva mumazana emishonga yakaongororwa yakatenderwa ne US Chikafu uye Dzvinyu Dhiza kurapwa kweAD, kusanganisira ina cholinesterase inhibitors-tetrahydroaminoacridine (Tacrine, iyo yakabviswa pamusika nekuda kwehupfu), donepezil (Aricept), rivastigmine (Exelon), uye galantamine (Razadyne) -imwe NMDA receptor modulator (memantine [Namenda] ]), uye musanganiswa wemantine uye donepezil (Namzaric). Ava vamiririri vakaratidza chete hunyanzvi hwekugadzirisa mhedzisiro ye Chirwere cheAlzheimer pakudzidza, ndangariro, uye kuziva kwenhambo pfupi zvikuru yenguva, asi ivo havana kuratidza miuyo inokosha pakukura kwechirwere. Neavhareji yechirwere chemakore 8-12 makore uye makore ekupedzisira anoda kuchengetwa nguva nenguva, mari inofungidzirwa yepasi rose yedementia muna 2018 yaive US $ 1 trillion uye izvi zvichakwira kuUS $ 2 trillion panosvika 2030. Iyi inofungidzirwa mutengo zvinotendwa kuti hazviremekedzwe zvakapihwa kuomerwa mukuongororwa kwedementia kuwanda uye mutengo. Semuenzaniso, Jia et al anofungidzira kuti mutengo wechirwere cheAlzheimer muChina wakanyanya kukwirira kupfuura iwo manhamba akashandiswa mu "World Alzheimer Report 2015" yakavakirwa paWang et al.
Yakagadzirwa mukuenderera mberi, AD inotanga nekiriniki asymptomatic preclinical phase uye inoenderera kuburikidza nechikamu chekutanga nyoro yekuziva kukanganisa (MCI; kana prodromal AD) inokanganisa kugona kuchengetedza ruzivo rutsva muyeuko ye episodic uye kurasikirwa kunofambira mberi kwendangariro dzekare kusati kwatungamira pakupedzisira kuratidzwa zvizere dementia.
KUBATSIRA KWEKUTANGA KUONA AD
Parizvino, kuongororwa kwechokwadi kweAD kuchiri kutsamira pakuongororwa kwepathological postmortem, kunyangwe ongororo iyi inogona kuve yakaoma. Kunyange hazvo kufambira mberi kwakakosha kwaitwa muAD biomarkers, kuongororwa nekiriniki kweAD kunoramba kuri maitiro ekubvisa zvimwe zvinokonzeresa dementia. Inofungidzirwa kuti inenge 50% yevarwere veAD havasi vakaonekwa munguva yehupenyu hwavo munyika dzakabudirira uye kunyange chirwere cheAlzheimer varwere vari munyika dzine mari yakaderera uye yepakati vangangove vasina kuongororwa.
Kusimbiswa kwekukurumidza kuonekwa nekuzotevera kupindira kwekutanga kwakawedzera kuwana traction senzira yakanakisisa yekuita kurwisa AD. Nhamburiko dzakakura dzakaitwa pakuzivikanwa kwezvinobudirira matanho ekudzivirira anogona kuderedza kuitika kwedementia uye chirwere cheAlzheimer. Zvidzidzo zvenguva refu zvekutevera zvakaratidza, semuenzaniso, kuti kuomerera kuMediterranean-Dietary Approaches to Stop Hypertension (DASH) Kupindira kweNeurodegenerative Delay (MIND) kudya kwaiva. yakabatana nekudzikiswa kwe53% mukukura kweAD uye kuti pakati pehupenyu hwepakati uye hwepfungwa zviitiko zvine chekuita nekudzikira kukuru kwedementia. kuvandudza ne caveat iyo mhando dzezvidzidzo dzakaoma kudzora.
Kunyangwe kuongororwa kwedementia muvanhu vasina zviratidzo hakuna kukurudzirwa neUnited States Preventative Services Task Force zvichibva pauchapupu huripo gore ra2012 risati rapera, kuongororwa muvanhu vane zviratidzo uye vari panjodzi huru Chirwere cheAlzheimer chakakosha pakukurumidza kuonekwa uye kuongororwa kwechirwere cheAlzheimer, uye chinonyanya kukosha pakugadzirira varwere uye nhengo dzemhuri kune ramangwana rechirwere chechirwere. Uyezve, kupihwa humbowo hutsva hwezvingangoita zvekudzivirira matanho uye mabhenefiti ekutanga kuongororwa kwechirwere cheAlzheimer iyo Alzheimer's Association inotsanangura mumushumo unokosha une musoro unoti "Alzheimer's Disease: Financial and Personal Benefits of Early Diagnosis" mune yayo 2018 "Alzheimer's Disease Figures and Facts" -kusanganisira zvekurapa, zvemari, zvemagariro evanhu, uye zvepfungwa zvatinotenda kuti United States Preventative. Services Task Force inogona kudzokorora kurudziro yavo munguva pfupi iri kutevera vachifarira kuongorora vanhu vanopfuura zera rakati pasina zviratidzo zveAD.
Episodic memory ndiyo yekutanga cognitive function inobatwa nechirwere cheAlzheimer uye kukurumidza kuonekwa kwechirwere cheAlzheimer kunodzivirirwa nekushaikwa kwechishandiso chiri nyore, chinodzokororwa, chakavimbika, chipfupi, uye chinonakidza chinopa otomatiki yekutevera mafambiro nekufamba kwenguva uye iri nyore kubata. Pane kudiwa kukuru kwe episodic memory assessment zviridzwa zvinosimbiswa uye zvinowanikwa zvakanyanya kuti zvishandiswe musha uye muhofisi yachiremba kuti vatarise uye nekukasika kuonekwa kwedementia uye chirwere cheAlzheimer. Kunyangwe kufambira mberi kwakaitwa pachishandiswa ropa uye cerebrospinal fluid biomarkers, kuongororwa kwemajini kune njodzi majini, uye kufungidzira kwehuropi (kusanganisira MRI uye positron-emission tomography) yekufungidzira uye. kuonekwa kwekutanga kweAlzheimer's Chirwere, matanho ekusaziva akadaro anongobatana kure nechirwere cheAlzheimer's pathology. Hapana chechokwadi chebiochemical marker parizvino inoratidza chero shanduko yehuropi zvine hukama neiyo yakakosha yechirwere cheAlzheimer, kunyanya shanduko uye kurasikirwa kwe synaptic basa rine chekuita nekukodha yeruzivo rutsva rwe episodic memory. Brain imaging inoratidzira kurasikirwa kwesynapse, iyo inotaridza sekunge kurasikirwa kwenzvimbo yemetabolism kana kuderera kwekuyerera kweropa, kana kuderera mumasynaptic mamaki muvarwere vapenyu, asi hazviratidzi zvakakwana kusakwana kwekuziva kwekuziva kunoratidza kuonda kwechirwere cheAlzheimer. Panguva iyo Apoe genotype inokanganisa zera reAD kutanga kwekutanga, amyloid biomarkers inongoratidzira kubatwa nedementia, uye tau ine hukama hwakaoma asi husiri hwakanangana nedementia. Matanho ese akadaro akaoma kuwana, anodhura, uye haagone kudzokororwa zviri nyore kana kakawanda. Hurukuro dzakadzama dzeizvi Alzheimer's ane hukama zvinhu zvakawanda mumabhuku uye vanofarira vaverengi vanogona kuongorora akati wandei ongororo uye mareferenzi mairi.
Kune marudzi matatu e Kuongorora kweKuongorora midziyo yekuongorora chirwere cheAlzheimer: (1) zviridzwa zvinotarisirwa nemupi wehutano; (2) zviridzwa zvinozviitira wega; uye (3) zvishandiso zvekuzivisa ruzivo. Ongororo iyi ichapfupisa muchidimbu izvo zviripo zvino zvinopihwa-anopa hutano-zvishandiso uye chimiro cheyega-yega chekuongorora chiridzwa chine mukana we (1) kuona kwekutanga AD-ane chekuita nekushanduka kwenjere zviratidzo zvisati zvatanga uye (2) kuongorora mafambiro echirwere.
AD SCREENING Instruments INOITWA NEMUPI WEUTANO
Zvinotevera zvinofanira kutariswa pakusarudza a Kuongororwa kwechirwere cheAlzheimer chiridzwa kana zviridzwa zvinowedzera:
- Zvinangwa uye marongero emushandirapamwe wekuongorora. Semuenzaniso, kune yakakura-yepasirese chirongwa chekuongorora chirwere cheAlzheimer, kushandisa chiri nyore-ku-kutungamirira, chakasimba, uye chinoshanda chiridzwa chingasarudzwa. Kune rumwe rutivi, munzvimbo yekiriniki, kururamisa uye kukwanisa kusiyanisa marudzi akasiyana edementia zvingave zvakanyanya kudiwa.
- Mari inotariswa, kusanganisira mutengo wechiridzwa uye heath-care-mupi wekudzidziswa uye nguva yekutonga.
- Kufunga kunoshanda, kusanganisira kugamuchirwa kwechiridzwa kune masangano anodzora, varapi, varwere; kureruka kwekutonga, zvibodzwa, uye kududzira zvibodzwa, kusanganisira chinangwa chechiridzwa (kureva, pesvedzero yenyanzvi/ chiremba anoongorora bvunzo pane zvese bvunzo uye zvibodzwa); nguva yakareba inodiwa kuti upedze; uye zvinodiwa zvakatipoteredza.
- Zviridzwa zvemidziyo zvinotariswa, zvinosanganisira: kunzwa kune zera, zvepabonde, dzidzo, mutauro, uye tsika; psychometric properties, kusanganisira dynamic range; kurongeka uye kurongeka; chokwadi uye kuvimbika, kusanganisira ruggedness (kuderedza shanduko dzine chekuita nekushandiswa kwechiridzwa kubva, semuenzaniso, vaongorori vakasiyana pamhedzisiro yebvunzo) uye kusimba (kuderedza kusiyanisa kwemhedzisiro yebvunzo ine chekuita nenzvimbo dzakasiyana uye nharaunda); uye hunhu uye sensitivity. Ruggedness uye kusimba zvinonyanya kukosha kufunga pakusarudza chiridzwa chekushandisa kune yakakura-mwero yenyika yeAlzheimer's chirwere chekuongorora chirongwa.
Chimbo chakakodzera chekuongorora chirwere cheAlzheimer chingave chinoshanda pabonde, zera, uye nehanya nazvo kuchinja kwekutanga kunoratidza Alzheimer's chirwere chisati chanyanya kuratidzwa kwezviratidzo zvekliniki. Uyezve, chiridzwa chakadaro chinofanirwa kunge chiri mutauro-, dzidzo-, uye tsika-chisina kwazvakarerekera (kana kuti chinokwanisa kuchinjika) uye chinokwanisa kushandiswa pasi rese nezvido zvishoma zvekusimbisa-tsika mutsika dzakasiyana. Chimbo chakadaro hachipo parizvino kunyangwe kuedza kwakatangwa munzira iyi nekuvandudzwa kwe MemTrax ndangariro bvunzo system, iyo ichakurukurwa muchikamu chinotevera.
Vanakiriniki vakatanga kugadzira zviridzwa zvekuongorora mu1930s uye nhamba huru yezviridzwa zvakagadziridzwa mumakore apfuura. Ongororo dzakanaka dzakaburitswa pazviridzwa zvinoverengeka-kusanganisira iyo Mini-Mental State Examination, iyo Montreal Cognitive Assessment (MoCA), iyo Mini-Cog, iyo Kukanganisa Kwendangariro Chidzitiro (MIS), uye Brief Alzheimer Screen (BAS)-inogona kushandiswa mukuvheneka nekuonekwa kwekutanga kwechirwere cheAlzheimer chinotungamirwa nemupi wehutano. Imwe yeakanyatso kugadziridzwa yekuongorora bvunzo ndeyeBAS, iyo inotora anenge maminetsi matatu. Chimwe nechimwe chezviridzwa izvi chinoyera chakasiyana asi chinowanzo pindirana seti yemabasa ekuziva. Zvinonyatsozivikanwa kuti bvunzo imwe neimwe ine yayo yakasarudzika maficha uye mashandisiro uye musanganiswa wezviridzwa zvinowanzo shandiswa kuita ongororo yakakwana mune yekiriniki mamiriro. Chekucherechedza, zvizhinji zvezviridzwa izvi zvakatanga kugadzirwa mumutauro weChirungu mumamiriro etsika dzekuMadokero uye naizvozvo zvinoda kujairana nezvose. Zvinocherechedzwa kunze zvinosanganisira Memory uye Executive Kuongorora (MES), iyo yakagadzirwa muChinese, uye Memory Alteration Test, iyo yakagadzirwa muchiSpanish.
tafura 1 inonyora zviridzwa zvakasimbiswa zvakakodzera kuongororwa kwechirwere cheAlzheimer pasi pezvirongwa zvakasiyana uye zvinokurudzirwa naDe Roeck et al zvichibva pakuongorora kwakarongeka kwezvidzidzo zveboka. Kune chidzitiro chehuwandu hwevanhu, MIS inokurudzirwa sechiridzwa chipfupi chekuongorora (<5 maminetsi) uye MoCA sechiridzwa chekutarisa chakareba (> maminitsi gumi). Miedzo iyi miviri yakatanga kugadzirwa muChirungu, uye MoCA ine shanduro dzakawanda neshanduro saka musiyano uripakati peshanduro unofanirwa kutariswa. Munzvimbo yekiriniki yekurangarira, MES inokurudzirwa kuwedzera kune MIS neMoCA kusiyanisa zviri nani pakati Chirwere cheAlzheimer's type dementia uye frontotemporal type dementia. Ndizvo zvakakosha kuziva kuti mhedzisiro yekuongororwa bvunzo hazvisi kuongororwa asi danho rekutanga rinokosha pakuonekwa uye kurapwa kwakakodzera kweAD nevarapi. Tafura 1. Inokurudzirwa kuongorora zviridzwa zvechirwere cheAlzheimer (AD) skrini inokurudzirwa naDe Roeck et al.
| Nguva (min) | ndangariro | mutauro | Orientation | Executive mabasa | tsika | Visuospatial kugona | Attention | akakodzera | Kunyatsozivikanwa kweAD | Sensitivity yeAD | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MIS | 4 | Y | Population-based Screen | 97% | 86% | ||||||
| Clinic | 97% | NR | |||||||||
| MoCA | 10-15 | Y | Y | Y | Y | Y | Y | Y | Population-based Screen | 82% | 97% |
| Clinic | 91% | 93% | |||||||||
| MAI | 7 | Y | Y | Clinic | 99% | 99% |
- AD, chirwere cheAlzheimer; MES, Memory uye Executive Screening; MIS, Memory Impairment Screen; MoCA, Montreal Cognitive Assessment; NR, isina kutaurwa; Y, inotaridzwa basa rakayerwa.
Nekuziva kuti Chirwere cheAlzheimer chinokura nekuenderera mberi kwenguva yakareba inogona kutenderera kumashure kwemakumi mashanu emakore kusati kwaratidzwa kwekuzara kwedementia., chiridzwa chinogona kudzokorodza kuyera episodic memory uye mamwe mabasa ekuziva, sekutarisa, kuita, uye kumhanya kwekupindura, kureba uye mumamiriro akasiyana (pamba maringe nenzvimbo yehutano) pasi rese, iri kudiwa zvakanyanya.
ZVINHU ZVINHU ZVINO ZVINHU ZVINOGONA KUZVITUNGAMIRIRA
Kuyera kwakarurama kwe Chirwere cheAlzheimer kubva pachikamu chayo chepreclinical kuburikidza nekufambira mberi kwayo kusvika kune dementia yakapfava inodiwa pakuziva chirwere cheAlzheimer nekukurumidza., asi chishandiso chakasimba hachisati chazivikanwa nekuda kwechinangwa ichi. Sezvo chirwere cheAlzheimer chiri kunyanya kusagadzikana kweuroplasticity, yepakati nyaya inova yekuzivisa chiridzwa kana zviridzwa zvinogona kunyatso ongorora chirwere cheAlzheimer shanduko dzakananga pamatanho ese echirwere cheAlzheimer. Izvo zvakakoshawo kuti ukwanise kuyera shanduko idzi uchishandisa metrics yepasirese kune huwandu hwevanhu asi hwakasiyana kune munhu nekufamba kwenguva, kuona kudyidzana pakati pechirwere cheAlzheimer uye sequelae yekuchembera kwakajairika, uye kuongorora kuti chidzidzo chiri papi pakuenderera mberi kwekutanga. kunzwisisa kunonoka yakabatana nechirwere cheAlzheimer maererano nekukwegura kwakajairika. Chiridzwa chakadaro kana zviridzwa zvaizoita kuti ive nechokwadi chekunyoreswa kwakaringana, kutevedzerwa kweprotocol, uye kuchengetwa kwezvidzidzo zvingangobatsirika kubva mukupindira mukurapa uye kugonesa dhizaini yekurapa uye kuongororwa kwekubudirira kwavo.
Kuongororwa kwe akati wandei dzidziso dzekuziva uye nzira dzekuongorora ndangariro dzakaratidza iyo inoenderera mberi recognition basa (CRT) separadigm ine hwaro hwakakodzera hwetioreti yekugadzira. kutanga kwechirwere cheAlzheimer mudziyo wokuyeresa. MaCRT akashandiswa zvakanyanya muzvirongwa zvedzidzo ku kudzidza episodic memory. Uchishandisa komputa yeCRT yepamhepo, episodic memory inogona kuyerwa chero nguva, kazhinji kakawanda pazuva. CRT yakadaro inogona kunyatsojeka kuyera shanduko dzisinganzwisisiki dzakabatanidzwa nekutanga Chirwere cheAlzheimer uye kusiyanisa shanduko idzi kubva kune dzimwe tsinga dzakakanganiswa uye dzakajairika kuchinja kwezera. MemTrax memory test yakagadziridzwa nekuda kweichi CRT imwe yakadaro online CRT uye yave kuwanikwa paWorld Wide Web kubvira 2005 (www.namXNUMXmetray.com) MemTrax ine huso hwakasimba- uye kuvaka-huchokwadi. Mifananidzo yakasarudzwa senzira yekukurudzira kuitira kuti pesvedzero yemutauro, dzidzo, uye tsika zvideredzwe kuti zvigadziriswe zviri nyore munyika dzakasiyana pasirese, izvo zvakaratidza kuve zvakadaro nekushandiswa kwechiChinese vhezheni muChina (www.memtrax. cn uye kuvandudzwa kweWeChat mini chirongwa vhezheni kugarisa maitiro emushandisi muChina).
The MemTrax ndangariro bvunzo inopa 50 stimuli (mifananidzo) kune zvidzidzo zvinorayirwa kuti zviende kune imwe neimwe kukurudzira uye kuona kudzokorora kwechimwe nechimwe chekukurudzira nemhinduro imwe chete inogadzirwa nokukurumidza sezvinogona nyaya. A MemTrax bvunzo inotora isingasviki 2.5-maminetsi uye zviyero kurongeka kwendangariro yezvinhu zvakadzidzwa (inomiririrwa sezana muzana [PCT]) uye nguva yekuzivikanwa (avhareji yekuita nguva yemhinduro dzakarurama [RGT]). MemTrax PCT matanho anoratidza zviitiko zveurourophysiological zvinoitika panguva yekukodha, kuchengetedza, uye kudzoreredza zvikamu zvinotsigira episodic memory. MemTrax RGT matanho anoratidza kushanda zvakanaka kwehuropi hwekuona sisitimu uye netiweki yekuziva yekuona iyo yakaoma inodzokororwa kukurudzira, pamwe nemukuru uye mamwe mabasa ekuziva uye kumhanya kwemota. Uropi hune matanho akati wandei ekugadzirisa ruzivo rwekuona uye nekuichengeta mune yakagoverwa network ye neuroni. Kumhanya kwekuzivikanwa kunoratidza kuti inguva yakawanda sei huropi network inoda kuti ienderane nekurudziro ichangobva kuratidzwa uye kuita mhinduro. Iko kushomeka kwekutanga kwechirwere cheAlzheimer ndiko kutadza kugadzwa kwetiweki encoding, kuitira kuti ruzivo ruve zvishoma nezvishoma kuchengetwa zvakaringana kuti runyatsozivikanwa kana kunyatsozivikanwa.
Uyezve, MemTrax inoongororawo inhibition. Nyaya inorayirwa kuti ipindure panguva yekuedzwa chete kana inodzokororwa kukurudzira / chiratidzo chiripo. Kurambwa kwakaringana ndekwekuti munhu asingapindure mufananidzo wakaratidzwa kekutanga. Nekuda kweizvozvo, chidzidzo chinofanirwa kuvharira kurudziro yekupindura kumufananidzo mutsva, izvo zvinogona kunyanya kunetsa mushure mekunge mifananidzo miviri kana mitatu inodzokororwa yakadzokororwa yaratidzwa. Nokudaro, mhinduro dzenhema-dzinoratidza chiratidzo chekushayikwa kwemaitiro ekudzivirira kwemashure epamberi, uye muenzaniso wakadaro wekukanganisa unowanikwa kune varwere vane frontotemporal dementia (Ashford, kliniki yekucherechedza).
MemTrax ikozvino yakashandiswa nevanhu vanopfuura 200,000 munyika ina: France (HAPPYneuron, Inc.); United States (Hutano Hutano Registry, mutungamiri mukutsvaga kwechirwere cheAlzheimer uye zvidzidzo zveMCI, Netherlands (Yunivhesiti yeWageningen); uye China (SJN Biomed LTD). Data kuenzanisa MemTrax neMoCA muvarwere vakura kubva kuNetherlands kunoratidza kuti MemTrax inogona kuongorora basa rekuziva kusiyanisa vakwegura vakajairwa kubva kuvanhu vane hunyoro. kusashanda zvakanaka kwepfungwa. Uyezve, MemTrax inoita seinosiyanisa Parkinsonian/Lewy muviri dementia (yakanonoka kucherechedzwa nguva) kubva kuAlzheimer's disease type dementia inoenderana nenguva yekuzivikanwa, iyo inogona kuita kuti iwedzere kuongororwa kwechokwadi. Chidzidzo chenyaya chakaburitswa chakaratidzawo kuti MemTrax inogona kushandiswa kuteedzera kushanda kwemaitiro ekurapa anobatsira mukurapa. kutanga kweAlzheimer's varwere vezvirwere.
Zvimwe zvidzidzo zvinodiwa kuona:
- Kunyatsoita kweMemTrax, kunyanya mukusiyanisa zvakajairika zvine chekuita nezera pakuziva, kusanganisira kudzidza nekuyeuka, kubva pakuchinja kwelongitudinal kwakabatana nekutanga AD.
- Iyo chaiyo hukama hweMemTrax metrics kune kuenderera kwe Kukura kwechirwere cheAlzheimer kubva pakutanga kudiki-diki kukanganiswa kwekuziva kusvika kune pakati nepakati dementia. Sezvo MemTrax ichigona kudzokororwa kazhinji, nzira iyi inogona kupa ruzivo rwekutanga uye inogona kuratidza shanduko yakakosha yekiriniki nekufamba kwenguva.
- Kunyangwe MemTrax inogona kuyera subject cognitive kuderera (SCD). Parizvino, hapana midziyo yekuongorora chinangwa inogona kuona SCD. MemTrax yakasarudzika zvivakwa inoda ongororo yakadzama yekushandisa kwayo kuona SCD uye chidzidzo chimwe chirikuenderera mberi muChina mune izvi.
- Iyo kusvika kune iyo iyo MemTrax bvunzo inogona kufanotaura shanduko yenguva yemberi muvarwere veAlzheimer's pachayo uye pamwe chete nemimwe miedzo uye biomarkers.
- Kushandiswa kwe MemTrax uye metrics inotorwa kubva kuMemTrax matanho ega kana pamwe chete nemamwe maedzo uye biomarkers seAlzheimer's. kuongororwa kwechirwere mukiriniki.
ZVINOKUDZIDZWA MAZVO
Kuti kugamuchirwe kwekiriniki uye munharaunda, panofanirwa kuve ne "kukodzera-mutengo" ongororo yekuona bvunzo yekubatsira kwekutanga kuona kwechirwere cheAlzheimer uye midziyo yekukurumidza kuona. Kana kuongorora chirwere cheAlzheimer kunofanirwa kutanga inyaya yakakosha inoda kutariswa mune ramangwana. Kutsunga uku kunonyanya kuenderana nekuti kusati kwatanga zviratidzo, kushomeka kwakakodzera kwekiriniki kunogona kuonekwa sei. Pane zvidzidzo zvinoratidza kuti yekutanga zvinoonekwa shanduko dzepfungwa dzine chekuita nekukura kwedementia zvinoitika makore 10 kusati kwatanga zviratidzo zvinoonekwa nekliniki. Zvidzidzo zveNeurofibrillary pa autopsy trace Alzheimer's disease kudzokera kumakore angangoita 50 uye inogona kutowedzera kusvika mukuyaruka. Hazvisati zvazivikanwa kana shanduko dzekutanga idzi dzinogona kushandurudzwa muzviratidzo zvinoonekwa zve kusagadzikana kwekuziva. Zvirokwazvo, zviridzwa zvemazuva ano hazvina mwero uyu wekunzwa. Mubvunzo zvino ndewekuti ramangwana, rinonyanya kunzwisiswa, bvunzo dzinogona kuona shanduko dzekare mukuziva basa rine chekuita nechirwere cheAlzheimer uye nehunyanzvi hwakakwana. Nekurongeka kweMemTrax, kunyanya nekuyedzwa kwakawanda kunowanzo kudzokororwa kwenguva yakareba, zvinogona kuitika kekutanga kuteedzera ndangariro uye. Kuchinja kwekuziva muvanhu vari panjodzi kweanopfuura makore gumi pamberi pekiriniki inoonekwa yekusagadzikana kwekuziva inovandudza. Dhata pamusoro pezvakasiyana zveepidemiological factor (semuenzaniso, kufutisa, hypertension, post-traumatic stress disorder, traumatic brain injury) inoratidza kuti vamwe vanhu vatove. inofarirwa nekukanganisa ndangariro uye/kana kukura dementia uye chirwere cheAlzheimer mumakore avo makumi mana kana kuti mberi. Huwandu hwevanhu vakapararira pa njodzi inoratidza kudiwa kwakajeka kwekuona uye kuona ekutanga ekuziva mamaki ekutanga neurodegeneration uye chirwere cheAlzheimer. nemidziyo yekuongorora yakakodzera.
ZVINONYANYA
Vanyori vanotenda Melissa Zhou nekutsoropodza kwake kuverenga kwechinyorwa.
VANHU VEMAGWARO
XZ yakatora chikamu mukutora ongororo uye kunyora manyoro; JWA yakatora chikamu mukupa zvirimo zvine chekuita neMemTrax uye nekudzokorora manyoro.