A 2023 Nhungamiro yeEpithalon

Tsvagiridzo inoratidza kuti Epitalon, inowanzopereterwa Epithalone, ianalog yekugadzira yeEpithalamin, polypeptide inogadzirwa mupineal gland. Kana iwe uchida kudzidza zvakawanda nezve peptide iyi, ramba uchiverenga iyo 2023 gwara reEpitalon peptide.

Muzvinafundo Vladimir Khavinson wekuRussia akaita kuwanikwa kwekutanga kweEpitalon peptide makore mazhinji apfuura[i]. Akaedza pamakonzo kwemakore 35 kuti adzidze zvakawanda nezve Epitalon basa.

Tsvagiridzo inoratidza kuti basa rekutanga reEpitalon kusimudzira mazinga e telomerase. Telomerase ndeye endogenous enzyme inofambisa kudzokororwa kwemasero etelomeres, iyo DNA endcaps. Kuita uku, kunokurudzira kudzokororwa kweDNA, inodiwa pakugadzira masero matsva uye kuvandudzwa kweakura, sezviri muongororo yakawanikwa.

Tsvagiridzo inoratidza kuti kugadzirwa kwetelomerase kwakakwira mumakonzo madiki kana zvichienzaniswa nemhuka dzakura. Ivo zvakare vanogadzira matelomere akareba, ayo anovandudza hutano hweserura uye kudzokorora.

Kugadzirwa kwetelomerase kunodzikira nezera mumakonzo, izvo zvinononotsa kuwanda kwesero. Apa ndipo panouya Epitalon inobatsira, sezvinoratidzwa nezvidzidzo zvekiriniki.

Epitalon inoita basa rei?

Epitalon inoshanda sei? Zvidzidzo zvemhuka zvakaratidza kushanda kwayo mukuenzanisa mwero wemetabolism, kuwedzera hypothalamic sensitivity, kuchengetedza anterior pituitary basa, uye kudzora mazinga emelatonin.

Tsvagiridzo inoratidza kuti DNA iri mukati mesero rega rega ine tambo mbiri; saka chisikwa chimwe nechimwe chine Epithalon peptide[ii] chakasiyana. Telomeres inogona kuwanikwa pamagumo eDNA tambo. Vanochengetedza kutevedzana kweDNA nekupikisa kupfupikiswa kwemakromosomes nechikamu chega chega chesero, sekuenderana nezvakawanikwa nekiriniki.

Tsvagiridzo inoreva kuti matelomere esero rega rega anove mapfupi nekuda kwekudzokorora kusina kukwana kunoitika nguva dzese masero paanopatsanura. 

Tsvakurudzo dzinoverengeka dzakabatanidza kupfupisa uku kune zvirwere zvakasiyana-siyana zvine hukama nezera, kusanganisira chirwere chemoyo uye kunyange kufa nguva isati yakwana mumakonzo.

Maererano nekutsvaga kwekutsvaga, huwandu hwepamusoro hweEpitalon hwave huchinzi "tsime rehuduku" nekuda kwehutano hwakanaka uye hupenyu.

Migumisiro Yekushandisa Epitalon

Epitalon ikemikari iyo, maererano nezvidzidzo zvakati[iii] inoitwa pamhuka nemakonzo, yakafanana neiyo inogadzirwa nemuviri wembeva. Iyi nzira inodzoreredza iyo cellular biological wachi, ichibvumira matishu akakanganisika kupora uye kudzoreredza basa renhengo.

Kwemakore akati wandei apfuura, masayendisiti muRussia akawana zvakawanda zvine chekuita neEpithalon. Semuenzaniso, masayendisiti akawana kuti inogona kumutsiridza kugadzirwa kwemasero etelomerase. Mukuwedzera, vanonzwisisa kuti inogona kumutsidzira muviri wose uye kugadzirisa hutano. Vakaona kuti inogona kudzoreredza kuchembera nekutarisa chikonzero chayo muzvidzidzo zvekutsvagisa.

Epitalon Peptide's Advantages

Zvidzidzo zvinoratidza kuti Epitalon ine mabhenefiti akati wandei. Mabhenefiti akanaka pahutano akaonekwa muzvidzidzo zvemhuka uchishandisa Epitalon peptide ndeaya anotevera:

• Inorebesa hupenyu hwembeva.
• Inobatsira kuchengetedza mhuka kubva mumamiriro ekuora, kusanganisira Alzheimer's, chirwere chemoyo, uye gomarara
• Kunowedzera kunaka kwekurara.
• Kuvandudzwa kwehutano hweganda
• Migumisiro pakusimba kwemasero emhasuru
• Inowedzera mwero wekupora
• Inoderedza lipid peroxidation uye kugadzirwa kweROS
• Kusimudza chikumbaridzo chekushushikana mupfungwa
• Inochengetedza huwandu hwakatsiga hwe melatonin mumakonzo

Kuwedzera kudzidza kweprotein iyi kunodiwa kuti udzidze zvizere mhedzisiro yayo. Kubva pane izvo vatsvakurudzi vakadzidza nezveEpithalon, zvisinei, zvinoratidzika kuti ichakurumidza kuwanikwa kurapa nekurapa matambudziko akawanda ehutano. Zvinotoshamisa, vaongorori vane tarisiro huru yekugona kweEpitalon sekurapa cancer nekudzivirira.

Pano, isu tichaongorora kushanda kweEpitalon peptide uye mashandisiro akawedzera kuitira kuti iwe ugone kusarudza kuti ungaisanganisira here muzvidzidzo zvako zvekutsvagisa.

Inoshanda Anti-Kukwegura Zvivakwa zveEpitalon

Biopeptide Epitalon yakaratidzwa kuwedzera hupenyu hwemakonzo ne25% mune chidzidzo chakanzi "The neuroendocrine theory of aging and degenerative disease," yakanyorwa naPurofesa Vladimir Dilmice uye Dr. Ward Dean mu1992.

Ongororo dzakawanda dzekutevera dzakaitwa neMutungamiri St. Petersburg Institute of Bio-regulation uye Purofesa Vladimir Khavinson vakasimbisa izvi zvekutanga.

Kugona kweEpitalon kugadzira peptide kubatana pakati peamino acids mazhinji, sezvakawanikwa nemasaenzi aya, inobatsira mukurebesa-kurebesa mhedzisiro. Zvinoenderana netsvagurudzo yakawanikwa, inogona zvakare kutadzisa bundu kukura uye kuwedzera huropi kuita.

Khavinson akawana, mumakonzo, kuti biopeptides yakawedzera mashandiro emuviri uye yakadzikisa kufa neanosvika 50% mushure memakore gumi nemashanu ekutariswa kwekiriniki.

Akapawo humbowo hwekuti kudyidzana pakati peEpithalon biopeptides neDNA kunogona kudzora zviitiko zvakakosha zvemajini, zvichinyatso kuwedzera hupenyu.

Zvidzidzo zvinoratidza kuti Epitalon yakawedzera hupenyu hwembeva zvichienzaniswa nemhuka dzakarapwa ne placebo kubva pazera remwedzi mitatu kusvika parufu. Zvinoenderana nemhedzisiro yekudzidza, chromosomal aberrations mumwongo maseru zvakaderedzwa zvakafanana mushure mekurapwa neEpitalon. Mbeva dzakarapwa neEpitalon zvakare dzakaratidza kusaratidza zviratidzo zvekutanga leukemia. Zvakawanikwa muchidzidzo ichi, zvakatorwa zvakazara, zvinoratidza kuti peptide iyi ine simba rekurwisa kuchembera uye inogona kushandiswa zvakachengeteka nekusingaperi.

Zvidzidzo zvinoverengeka zvemhuka zvinosimbisa zvinotevera mhedzisiro yeEpitalon:

• Cortisol uye melatonin synthesis inononoka nezera mutsoko, izvo zvinobatsira kuchengetedza yakatsiga cortisol rhythm.
• Kuberekesa kwemakonzo kwakadzivirirwa kuti kusakuvadzwa, uye kukanganiswa kwakagadziridzwa.
• Chimiro che retinal chinoramba chakasimba pasinei nekufambira mberi kwechirwere mu retinitis pigmentosa.
• Makonzo ane makonzo egomarara akawana kuderera kwekukura.

Impact paGanda 

Zvidzidzo zvemhuka zvakaratidza kuti kunze kweiyo anti-aging properties, Epitalon inovandudzawo hutano hweganda.

Maererano nekutsvakurudza kwaDr. Khavinson, Epithalon inogona kukurudzira masero[iv] ari kutarisira kugadzirisa nekuchengetedza matrix ekunze anochengetedza ganda rine utano uye vaduku. Collagen uye elastin maviri anopesana nekuchembera superstars mune extracellular matrix.

Zvidzidzo zvinoratidza kuti akawanda anorwisa-kuchembera lotions anovimbisa kusimbisa collagen muganda, asi Epitalon chete anoita saizvozvo. Epithalon inopinda mumasero uye inokurudzira kuwedzera uye kukura kwefibroblasts inokonzera kugadzira collagen nemamwe mapuroteni. Nekuda kweizvozvo, izvi zvinosimudzira hutano kuvandudzwa kweganda, maererano nezvakawanikwa zvekutsvaga.

Ongororo dzinoratidza kuti, zvisinei, Epithalon peptide inoshanda kupesana nemhedzisiro yekukwegura kupfuura izvo zvinosangana neziso. Chirwere, kutapukirwa, uye kukuvara ndizvo zvese zvazvinogona kudzivirira. Ganda rekare rinova rakaoma, risina kusimba, uye rinowanzobvaruka. Sezvinoratidzwa nemiedzo yekiriniki, kushandisa Epitalon paganda kunogona kudzivirira mhedzisiro yakadaro.

Kurapa kweRetinitis Pigmentosa 

Tsvimbo mu retina inoparadzwa nechirwere chinodzikira chinonzi retinitis pigmentosa. Kana chiedza charova retina, chinoparira kuburitswa kwemashoko emakemikari kuburikidza netsvimbo. Epitalon yakaratidzwa kuderedza kuparara kwekukuvadza kune retina kunokonzerwa nekusagadzikana mukuongororwa kwekliniki.

Epitalon inovandudza retinal basa mumakonzo bvunzo nekumisa kuderera kwesero uye kuchengetedza tsvimbo, sekuenderana nezvidzidzo zvekutsvaga.

Tsvagiridzo inoratidza kuti Epitalon inobudirira kurapa retinitis pigmentosa mukutsvagisa kunosanganisira mbeva nemakonzo. Nekudaro, kumwe kuongorora kunodiwa kuti uone mhedzisiro iyi. Pano unogona tenga peptides online.

[I] Anisimov, Vladimir N., uye Vladimir Kh. Khavinson. "Peptide Bioregulation Yekuchembera: Mhedzisiro uye Tarisiro." Biogerontology 11, kwete. 2 (Gumiguru 15, 2009): 139–149. doi:10.1007/s10522-009-9249-8.

[ii] Frolov, DS, DA Sibarov, uye AB Vol'nova. "Altered Spontaneous Electric Activity Yakawanikwa muRat Motor Neocortex mushure meIntranasal Epitalon Infusions." PsychEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). AEDG Peptide (Epitalon) Inokurudzira Gene Expression uye Protein Synthesis panguva Neurogenesis: Zvinogoneka Epigenetic Mechanism. Mamorekuru, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, NI, NS Linkova, AN Zhekalov, AO Orlova, GA Ryzhak, naV. Kh. Khavinson. "Pfupi Peptides Inosimudzira Kuberekwazve Kwesero muGanda Munguva Yekukwegura." Kufambira mberi muGerontology 5, kwete. 3 (Chikunguru 2015): 176-179. doi: 10.1134 / s2079057015030054.

[v] Korkushko, OV, V. Kh. Khavinson, VB Shatilo, uye LV Magdich. "Mhosva yePeptide Kugadzirira Epithalamin paCircadian Rhythm yeEpiphyseal Melatonin-Kugadzira Basa muVanhu Vakwegura." Bulletin yeExperimental Biology uye Medicine 137, kwete. 4 (Kubvumbi 2004): 389–391. doi:10.1023/b:bebm.0000035139.31138.bf.