Alzheimer's Speaks Radio Interviews MemTrax: Kupeza Munthu Ndi Dementia - Gawo 2
Sabata yatha, mu athu Blog positi, tinayamba kuyankhulana kwathu kwa Alzheimer's Speaks Radio ndi mawu oyamba kwa Dr. Ashford, woyambitsa wa Mayeso a MemTrax, ndi mwachidule za Lori La Bey ndi mbiri yake yolimbana ndi Dementia. Mlungu uno Dr. Ashford ndi ine tikukambirana za Agogo athu amene anali ndi matenda a Alzheimer ndipo tikuwafotokozera mmene zinkakhalira atadwala matenda oopsawa. Sabata ino tilemba zambiri zoyankhulana ndikupereka chidziwitso chothandiza kulimbikitsa kafukufuku wa matenda a Alzheimer's.
Gawo 2: Kuwunika Mayeso a MemTrax ndi Kuchuluka kwa Dementia
Lori:
Tisanalowe m'mafunso athu ndikufunanso ndidziwitse Curtis Ashford, yemwe ndimakhulupirira kuti ndi mwana wanu, ndipo adayamba chidwi ndi kuyesa kwa chidziwitso ngati undergraduate ku California State University ku San Jose (Silicon Valley) komwe adamaliza maphunziro ake mu 2011 M'zaka zapitazi za 3 wakhala akugwira ntchito limodzi kuti apange ntchito yosavuta yowunikirayi kuti awone kusintha kwa kukumbukira pogwiritsa ntchito ma TV, makompyuta, ndi intaneti kuti adziwitse ndi kulimbikitsa kuwunika kukumbukira pafupipafupi komanso kosasintha. Curtis ali wokonda kulimbikitsa kuzindikira koyambirira kwa kusintha kwamakumbukidwe komwe kungakhale kuwonetsa kuyambika kwa matenda a Alzheimer's kapena kupezeka kwa zinthu zina zomwe zimayambitsa vuto lachidziwitso. Pakali pano akutsogolera MemTrax pakupanga kuwunika kwachidziwitso mapulogalamu omwe ali ndi chidwi chowunika kusintha koyambirira kwa kukumbukira komanso kulimbikitsa kulowererapo koyambirira kulumala kusanachitike. Takulandirani Curtis, muli bwanji lero?
Curtis:
Moni Lori, zikomo kwambiri chifukwa chokhala nafe lero!
Lori:
Chabwino ndangosangalala, ndamva za kampani yanu kwatha chaka tsopano ndipo chimodzi mwazinthu zomwe ndikufuna kukufunsani nonse, ndiyamba ndi Curtis pano. Kodi mwakhudzidwapo panokha m'banja mwanu kapena bwenzi lapamtima la dementia, omvera athu amakonda kumva ngati pali pang'ono.
Curtis:
Inde, agogo anga aamuna kwenikweni, agogo anga aamuna a John anali ndi vuto lalikulu. Ndinali wamng’ono ndithu, pafupifupi 14 kapena 15, pamene anayamba kufooka. Ndinkacheza naye, ndipo zinali zomvetsa chisoni kwambiri chifukwa nthawi iliyonse ukapitanso kukacheza ankayiwalako pang’ono za inuyo kapena bambo anga kapena amangoyiwala dzina la munthu wina. Mutha kuyambiranso nthawi iliyonse ndipo mukudziwa kuti china chake chikuchitika.
Lori:
Mmm, pa. Dr. Ashford, nanga bwanji inu, kodi anali bambo anu amene anali ndi vuto la maganizo kapena anali mbali inayo?
Dr. Ashford:
Ayi, anali bambo anga.
Chidwi changa pa izi chinachokera ku njira yosiyana, pamene ndinali ku Berkeley chidwi changa pambali pa ndale zonse zinali kuyesera kukhala ndi moyo kosatha kotero ndinali ndi chidwi kwambiri ndi ukalamba, ndi momwe ndingaletsere. Pamene ndinali kuliphunzira mowonjezereka ndinayamba kuona ubongo monga chiwalo chachikulu chimene chimayang’anira chirichonse, ndipo ndinalingalira kuti ngati nditi ndimvetse kachitidwe ka ukalamba ndiyenera kumvetsetsa mmene ubongo umatetezera ukalamba. M’kupita kwa nthaŵi ndinazindikira kuti sindingathe kuletsa ukalamba, ndiyenera kukhala ndi moyo wabwino koposa. Ndinali ndi chidwi ndi njira za ukalamba ndipo zinapezeka kuti pamene ndinayang'ana chiwerengero cha anthu ndi ana aang'ono, omwe ine ndiri membala, kukalamba, pali zinthu zambiri zomwe tingachite kuti tipewe kufa; osasuta ndudu, kukhala ndi moyo wathanzi, kuvala malamba, ndikuthawa mavuto ambiri omwe angakuchititseni kufa. Koma pamene ndinaphunzira zinthu mochulukira, vuto lalikulu lomwe ndinawona ndikuyembekezera linali matenda a Alzheimer, ndipo pamene ana akumakula ndikudzisamalira bwino ndikukhala ndi moyo wautali ndi wautali, vuto la Alzheimer's lidzakhala vuto. vuto lowononga kwambiri lazaka zana.
Chifukwa chake ndidachita chidwi ndi matenda a Alzheimer's malinga ndi Public Health. Mu 1978, ndinali woyamba kukhala wamkulu pa geriatric psychiatry unit ku UCLA ndipo ndinayamba kuona kuti pafupifupi 2 mwa 5 odwala onse amene tinavomereza sakanakhoza kukumbukira kanthu. Ndikawafunsa kuti akumbukire mawu 5 ndipo mwachiwonekere aliyense amatha kukumbukira mawu osavuta awa, ndikabweranso ndikunena kuti ndi mawu ati omwe ndinakufunsani kuti mukumbukire? Kenako anthu 2 mwa 5 aliwonse sankakumbukira n’komwe kuti ndinawapempha kuti akumbukire mawu 5, ndipo ndinakhala ngati, “izi sizimveka.” Ndinali ndi chidwi kwambiri ndi kukumbukira kale, mlangizi wanga anali Pulofesa Lissy Jarvik, yemwe ankaphunzira matenda a Alzheimer's. Choncho tinaganizira za vutolo. Mwachiwonekere tinkaganiza kuti matenda a Alzheimer ndi ofala kwambiri kuposa momwe aliyense amaganizira, ndipo ndibwino kuti tiyambe kuchita chidwi ndi zomwe tiyenera kuchita nazo. Tinaphunzira zina mwazomwe asayansi apeza zomwe zidangotuluka kumene zomwe zidazindikira njira zenizeni muubongo zomwe zidakhudzidwa ndi matenda a Alzheimer's omwe amakhudza mankhwala otchedwa Acetyl-choline. Kotero ife tinaganiza njira yoyesera kuonjezera kuchuluka kwa Acetyl-choline mu ubongo ndi zomwe zimatitsogolera ife kugwiritsa ntchito mankhwala otchedwa physostigmine omwe ndi mankhwala ofanana ndi omwe amagwiritsidwa ntchito pochiza matenda a Alzheimer's, monga donepezil (Aricept) kapena galantamine ( Razadyne), kapena rivastigmine (Excelon ndi Excelon chigamba). Tidachita ntchitoyi mu 1978-1979 ndikusindikiza mu 1981 kotero kuti linali lingaliro loyesera kuchiza odwala omwe ali ndi matendawa, ndipo panali kufanana kwambiri ndi kugwiritsa ntchito mankhwalawa ndi omwe amagwiritsidwa ntchito pa Parkinson.
Chimene ndinazindikira mwamsanga chinali chakuti mankhwalawa saletsa matenda a Alzheimer amaoneka kuti amathandiza pang'ono, koma samasiya. Tiyenera kumvetsetsa matendawa kuti tithe kuyimitsa matendawa kwathunthu, ndipo ndikukhulupirirabe kuti ndizotheka, ndipo ngati titha kupita kunjira yoyenera yofufuza ndikukhulupirira kuti titha kuthetsa matenda a Alzheimer's kwathunthu, koma titha kumvetsetsa. za zomwe ndondomekoyi ili. Ndipamene ndinayamba kupanga chiphunzitso cha neuroplasticity ndi momwe neuroplasticity ndizomwe zimawukiridwa muubongo ndi Alzheimer pathology. Panali pepala lomwe linatuluka mu Journal yotchedwa "Kukalamba," September 2014, ndi mnzanga wina, Dale Bredesen, yemwe amayendetsa Buck Institute on Aging ku Northern California, ndipo ali ndi pepala lotchedwa "Reversal of Cognitive Decline". , A Novel Therapeutic Programme,” ndipo akugwiritsa ntchito chiphunzitso chomwe ndinachipanga kale mu 2002, kuti ngati mumvetsetsa njira zenizeni zomwe Alzheimer's imawonongera ubongo, mutha kusintha zinthu zambiri muzakudya zanu ndi chilengedwe zomwe zitha kusiya. ndondomeko imeneyi kwathunthu. Izi ndi zomwe tikufuna kuchita, sitikufuna kuti anthu alandire chithandizo cha Alzheimer's, tikufuna kuti apewedwe. Ndine wokondwa kuyankhula nanu zambiri za izi.
Lori:
Zolondola. Chabwino, ndizodabwitsa, ndikudziwa kuti Alzheimer's Disease International yangotuluka ndi lipoti lalikulu lokhudza kuchepetsa chiopsezo chomwe ndikudziwa Mart Wortman, Woyang'anira wamkulu, anali wachindunji kuti ichi sichinali chitsimikizo. Mukudziwa kuti zinthu zonsezi zomwe akuzitchulazi ndizabwino kwa thupi lathu lonse koma ndizowona kuti sizingapweteke kukhala olimbikira popititsa patsogolo zinthu.