A 2023 Guide to Epithalon

Kafukufuku akuwonetsa kuti Epitalon, yomwe nthawi zambiri imatchedwa Epithalone, ndi analogi yopangidwa ndi Epithalamin, polypeptide yopangidwa mu pineal gland. Ngati mukufuna kudziwa zambiri za peptide iyi, pitilizani kuwerenga buku la 2023 la Epitalon peptide.

Pulofesa Vladimir Khavinson waku Russia adapeza koyamba za Epitalon peptide zaka zambiri zapitazo[i]. Anayesa mbewa kwa zaka 35 kuti aphunzire zambiri za ntchito ya Epitalon.

Kafukufuku akuwonetsa kuti ntchito yayikulu ya Epitalon ndikukulitsa kuchuluka kwa ma telomerase. Telomerase ndi endogenous enzyme yomwe imathandizira kugawanika kwa ma telomeres, ma DNA endcaps. Kuchita zimenezi kumalimbikitsa kugawanika kwa DNA, komwe kumafunika kuti maselo atsopano apangidwe ndi kupangidwanso kwa okalamba, monga momwe kafukufuku wapeza.

Kafukufuku akuwonetsa kuti kupanga ma telomerase ndikwambiri mu mbewa zazing'ono poyerekeza ndi nyama zakale. Amapanganso ma telomere ataliatali, omwe amapangitsa kuti ma cell azikhala ndi thanzi komanso kubwerezabwereza.

Kupanga kwa telomerase kumachepa ndi kukula kwa mbewa, zomwe zimachepetsa kuchuluka kwa maselo. Apa ndi pamene Epitalon imabwera bwino, monga momwe maphunziro azachipatala akuwonetsera.

Kodi Epitalon imagwira ntchito yanji?

Kodi Epitalon imagwira ntchito bwanji? Kafukufuku wa zinyama awonetsa mphamvu yake pakuwongolera kuchuluka kwa kagayidwe kachakudya, kukulitsa chidwi cha hypothalamic, kusunga magwiridwe antchito apituitary, ndikuwongolera kuchuluka kwa melatonin.

Kafukufuku akusonyeza kuti DNA yomwe ili m’kati mwa selo iliyonse ili ndi zingwe ziwiri; chifukwa chake cholengedwa chilichonse chokhala ndi Epithalon peptide[ii] chimakhala chosiyana. Ma telomere amatha kupezeka kumapeto kwenikweni kwa zingwe za DNA. Amasunga kukhulupirika kwa DNA polimbana ndi kufupikitsidwa kwa ma chromosome ndi gawo lililonse la selo, malinga ndi zomwe zapeza kuchipatala.

Kafukufuku akusonyeza kuti ma telomere a selo lililonse amakhala aafupi chifukwa cha kugawanikana kopanda ungwiro komwe kumachitika nthawi zonse pamene maselo agawanika. 

Kafukufuku angapo adalumikiza kufupikitsa uku ndi matenda osiyanasiyana okhudzana ndi ukalamba, kuphatikiza matenda amtima komanso kufa msanga kwa mbewa.

Malinga ndi zomwe zapezedwa, kuchuluka kwa Epitalon kumatchedwa "kasupe wa unyamata" chifukwa cha zotsatira zake zabwino pa thanzi ndi moyo wautali.

Zotsatira Zogwiritsa Ntchito Epitalon

Epitalon ndi mankhwala omwe, molingana ndi maphunziro angapo[iii] omwe amachitidwa pa nyama ndi mbewa, amakhala ofanana ndi omwe amapangidwa ndi thupi la mbewa. Izi zimabwezeretsanso mawotchi achilengedwe a ma cell, zomwe zimapangitsa kuti minyewa yowonongeka ichiritse ndikubwezeretsa magwiridwe antchito amthupi.

Kwa zaka zingapo zapitazi, asayansi ku Russia atulukira zinthu zambiri zokhudza Epithalon. Mwachitsanzo, asayansi apeza kuti imatha kutsitsimutsanso kupanga ma cell a telomerase. Kuphatikiza apo, amamvetsetsa kuti imatha kutsitsimutsa thupi lonse ndikuwongolera thanzi. Iwo adapeza kuti imatha kusinthanso ukalamba poyang'ana zomwe zidayambitsa m'maphunziro ofufuza.

Ubwino wa Epitalon Peptide

Kafukufuku akuwonetsa kuti Epitalon ili ndi maubwino angapo. Ubwino wabwino paumoyo womwe wawonedwa m'maphunziro a nyama pogwiritsa ntchito Epitalon peptide ndi motere:

• Amatalikitsa moyo wa mbewa.
• Imathandiza kuti nyama zisawonongeke, monga Alzheimer's, matenda amtima, ndi khansa
• Kumawonjezera ubwino wa kugona.
• Kupititsa patsogolo thanzi la khungu
• Zotsatira pa mphamvu ya maselo a minofu
• Amachulukitsa kuchuluka kwa kuchira
• Amachepetsa lipid peroxidation ndi kupanga ROS
• Kukweza malire a kupsinjika maganizo
• Imasunga kuchuluka kwa melatonin mu mbewa

Kuphunzira zambiri za puloteniyi kumafunika kuti mudziwe zotsatira zake zonse. Kuchokera ku zomwe ochita kafukufuku aphunzira za Epithalon, komabe, zikuwoneka kuti posachedwapa zidzapezeka kuchiza ndi kuchiza matenda ambiri. Chodabwitsa kwambiri, ofufuza ali ndi chiyembekezo chachikulu cha kuthekera kwa Epitalon ngati chithandizo cha khansa komanso kupewa.

Apa, tiwona mphamvu ya Epitalon peptide ndi kugwiritsa ntchito kwake mwatsatanetsatane kuti mutha kusankha kuti muyiphatikize mu kafukufuku wanu.

Zothandiza Zotsutsa Kukalamba za Epitalon

Biopeptide Epitalon inasonyezedwa kuti ikuwonjezera miyoyo ya makoswe ndi 25% mu phunziro lotchedwa "The neuroendocrine theory of aging and degenerative disease," lolembedwa ndi Pulofesa Vladimir Dilmice ndi Dr. Ward Dean mu 1992.

Kafukufuku wotsatiridwa ndi Purezidenti St. Petersburg Institute of Bio-regulation ndi Pulofesa Vladimir Khavinson adatsimikizira zotsatirazi zoyamba.

Kuthekera kwa Epitalon kupanga kugwirizana kwa peptide pakati pa ma amino acid ambiri, monga momwe asayansi awa amapezera, kumathandizira kuti pawiriyi ikhale ndi moyo wautali. Malinga ndi zomwe kafukufuku wapeza, zitha kulepheretsanso kukula kwa chotupa ndikuwonjezera ntchito zaubongo.

Khavinson adapeza, mu mbewa, kuti biopeptides imathandizira kwambiri magwiridwe antchito amthupi ndikuchepetsa kufa ndi pafupifupi 50% pambuyo pa zaka 15 zakuwunika kwachipatala.

Anaperekanso umboni wosonyeza kuti kuyanjana pakati pa Epithalon biopeptides ndi DNA kungathe kulamulira zochitika zofunika kwambiri za majini, kukulitsa moyo wautali.

Kafukufuku akuwonetsa kuti Epitalon adakulitsa moyo wa mbewa poyerekeza ndi nyama zothandizidwa ndi placebo kuyambira ali ndi miyezi itatu mpaka kufa. Malinga ndi zotsatira za kafukufuku, kusintha kwa chromosomal m'maselo a mafupa kunachepetsedwa chimodzimodzi pambuyo pa chithandizo ndi Epitalon. Makoswe omwe amathandizidwa ndi Epitalon nawonso sanawonetse zizindikiro za khansa ya m'magazi. Zotsatira za kafukufukuyu, zomwe zatengedwa lonse, zikuwonetsa kuti peptide iyi ili ndi mphamvu yoletsa kukalamba ndipo ingagwiritsidwe ntchito motetezeka mpaka kalekale.

Maphunziro angapo a nyama amatsimikizira zotsatirazi za Epitalon:

• Kaphatikizidwe ka Cortisol ndi melatonin kumachepetsa ndikukula kwa anyani, zomwe zimathandiza kuti nyimbo ya cortisol ikhale yokhazikika.
• Njira zoberekera za makoswe zinali zotetezedwa kuti zisavulazidwe, ndipo zowonongeka zinakonzedwanso.
• Kapangidwe ka retina kamakhalabebe ngakhale kuti matendawa akupita patsogolo mu retinitis pigmentosa.
• Makoswe okhala ndi khansa ya m'matumbo adakula pang'onopang'ono.

Impact pa Khungu 

Kafukufuku wa zinyama awonetsa kuti kuwonjezera pa zotsutsana ndi ukalamba, Epitalon imapangitsanso thanzi la khungu.

Malinga ndi kafukufuku wa Dr. Khavinson, Epithalon ikhoza kulimbikitsa maselo[iv] omwe amayang'anira kukonza ndi kusunga matrix owonjezera omwe amachititsa kuti khungu likhale labwino komanso laling'ono. Collagen ndi elastin ndi nyenyezi ziwiri zotsutsana ndi ukalamba mu matrix a extracellular.

Kafukufuku akuwonetsa kuti mafuta odzola angapo oletsa kukalamba amalonjeza kulimbitsa collagen pakhungu, koma Epitalon yekha ndi amene amachita. Epithalon imalowa m'maselo ndikulimbikitsa kukula ndi kusasitsa kwa fibroblasts yomwe imayambitsa kupanga collagen ndi mapuloteni ena. Chifukwa chake, izi zimathandizira kukonzanso khungu lathanzi, malinga ndi zomwe kafukufuku wapeza.

Mayesero amasonyeza kuti, komabe, Epithalon peptide imagwira ntchito motsutsana ndi zotsatira za ukalamba kupitirira zomwe zimakumana ndi diso. Matenda, matenda, ndi kuvulala ndizo zonse zomwe zingatetezedwe. Khungu lokalamba limakhala louma, losalimba komanso losavuta kung'ambika. Monga momwe mayesero achipatala amasonyezera, kugwiritsa ntchito Epitalon pakhungu kungalepheretse zotsatira zoterezi.

Chithandizo cha Retinitis Pigmentosa 

Ndodo za retina zimawonongedwa ndi matenda osokonekera otchedwa retinitis pigmentosa. Kuwala kukalowa mu retina, kumatulutsa mauthenga a mankhwala kudzera mu ndodo. Epitalon adawonetsedwa kuti achepetse kuwonongeka kwa retina komwe kumayambitsidwa ndi vutoli pakufufuza kwachipatala.

Epitalon imathandizira kugwira ntchito kwa retina pamayeso a makoswe poyimitsa kuwonongeka kwa ma cell ndikusunga mawonekedwe a ndodo, malinga ndi kafukufuku wofufuza.

Kafukufuku akusonyeza kuti Epitalon ndi mankhwala opambana a retinitis pigmentosa pa kafukufuku wokhudza mbewa ndi makoswe. Komabe, kufufuza kwina kumafunika kutsimikizira zotsatira izi. Apa mungathe gula peptides pa intaneti.

[I] Anisimov, Vladimir N., ndi Vladimir Kh. Khavinson. "Peptide Bioregulation of Ukalamba: Zotsatira ndi Zoyembekeza." Biogerontology 11, no. 2 (October 15, 2009): 139-149. doi:10.1007/s10522-009-9249-8.

[Ii] Frolov, DS, DA Sibarov, ndi AB Vol'nova. "Zosintha Zamagetsi Zamagetsi Zomwe Zapezeka mu Rat Motor Neocortex pambuyo pa Intranasal Epitalon Infusions." PsychEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). AEDG Peptide (Epitalon) Imalimbikitsa Mawonekedwe a Gene ndi Mapuloteni Kaphatikizidwe pa Neurogenesis: Possible Epigenetic Mechanism. Mamolekyu, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, NI, NS Linkova, AN Zhekalov, AO Orlova, GA Ryzhak, ndi V. Kh. Khavinson. "Ma Peptide Aafupi Amalimbikitsa Kubadwanso Kwamaselo Pakhungu Panthawi Yokalamba." Zotsogola mu Gerontology 5, No. 3 (Julayi 2015): 176-179. onetsani: 10.1134 / s2079057015030054.

[v] Korkushko, OV, V. Kh. Khavinson, VB Shatilo, and LV Magdich. "Zotsatira za Peptide Preparation Epithalamin pa Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Okalamba." Bulletin of Experimental Biology and Medicine 137, no. 4 (April 2004): 389-391. doi:10.1023/b:bebm.0000035139.31138.bf.