LEFU LA ALZHEIMER: NA NEURON PLASTICITY E RATA HO AXONAL NEUROFIBRILLARY DEGENERATION?
New England Journal of Medicine, Moq. 313, leqepheng la 388-389, 1985
LEFU LA ALZHEIMER: NA NEURON PLASTICITY E REBELLA HO HLOKA AXONAL NEUROFIBRILLARY?
Ho Mohlophisi: Gajdusek o nahana hore tšitiso ea li-neurofilaments ke motheo oa mafu a 'maloa a dementia (taba ea 14 March). 1 Ho hlalosa hore na ke hobane'ng ha li-neuron tse ling bokong li ameha eseng tse ling, o fana ka maikutlo a hore lisele tse nang le lifate tse kholo tsa axonal, ka lebaka la litlhoko tsa tsona tse kholo tsa lipalangoang tsa axonal, li kotsing ka ho khetheha ho senyeha ha axoskeletal. Khopolo-taba ea Gajduseks e khahla empa e hloleha ho ikarabella bakeng sa tlhokomeliso ea hore methapo e meholo ea methapo ea kutlo e ameha hanyane ho lefu la Alzheimer's.
Re fana ka maikutlo a hore polasetiki ea sele hammoho le boholo ba sefate sa axonal li ka 'na tsa beha litlhoko tsa ho tsamaisa axonal. Plastiki ea lisele tsa neural e amana le lintlha tse fapaneng tsa trophic,2 tse ling tsa tsona li ama sepalangoang sa axonal. Mohlala o nepahetseng ke ho mela ho bonoang li-terminals tsa septal norepinephrine,3 ho ka etsahala hore ebe e tsamaisana le phallo e kholo ea li-neurofilaments tse ncha.
Li-neurone tse bontšang boemo bo phahameng ba polasetiki mohlomong li etsa karoloana ea memori le thuto; ka bobeli ba holofetse ke lefu la Alzheimer. Litsela tsa Norepinephrine li 'nile tsa amahanngoa le thuto e amanang le moputso,4' me lisele tsa norephinephrine tsa locus ceruleus li timetsoa maemong a mang. Lefu la Alzheimer.5 Ho senyeha ha Alzheimer ho boetse ho senya sebaka sa tšimoloho ea lisele tsa serotonin bohareng ba raphe,6 le serotonin e 'nile ea hlahisoa e le mokena-lipakeng oa boemo ba khale.7 Acetylcholine pathways projecting from nucleus basalis of Meynert to the cortex e ka ba le karolo. ea latchkey mohopolong o rarahaneng ho boloka le ho khutlisa,8.9 le joalokaha ho tsebahala, lefu la Alzheimer le amahanngoa le tahlehelo ea lisele tsena hammoho le li-enzyme. 10 tseo ka bobeli li bapalang karolo e kholo mohopolong.11 Ho feta moo, ho senyeha ha neurofibrillary ho etsahala ka mokhoa o ikhethileng ho li-neurone tse nang le li-axon tse kopanyang hippocampus le entorhinal cortex. boemo bo phahameng ba polasetiki, ho senyeha ha bona ho tšehetsa maikutlo a hore lisele tse bontšang polasetiki e ngata li na le bothata ba ho senyeha ha neurofibrillary.
Ho senyeha ha mochine o tsamaeang butle oa li-axonal-transport ka li-neurone tse nang le tekanyo e phahameng ea polasetiki ho ka lebisa ho se sebetse hantle ha mohopolo, e leng letšoao la mantlha la 'dementia' ho sa tsotelehe sesosa. Ho se sebetse hona ha axonal-filament ho ka fana ka motheo oa micropathological bakeng sa sehokelo se neng se ngotsoe pele lipakeng tsa microtubular diathesis le mofuta oa Alzheimer. 'dementia' 15,16 le ho kopanya sehlopha se senyane sa mafu a dementia.
J. Wesson Ashford, MD, Ph.D.
Lissy Jarvik, MD, Ph.D.
UCLA Neuropsychiatric Institute
Los Angeles, CA 90024