Ho nepahala ha MemTrax Teko ea Khopolo Bapisoa le ea Tlhahlobo ea Temoho ea Montreal ho Fumana Bofokoli bo Bonolo ba Kelello le 'dementia' ka lebaka la Lefu la Alzheimer sehlopheng sa Machaena.

 

Xiaolei Liu, Xinjie Chen , Xianbo Zhou , Yajun Shang, Fan Xu , Junyan Zhang, Jingfang He, Feng Zhao, Bo Du, Xuan Wang, Qi Zhang, Weishan Zhang, Michael F Bergeron, Tao Ding, J Wesson Ashford, Lianmei Zhong

  • PMID: 33646151
  • DOI: 10.3233/JAD-200936

inahaneloang

 

Background: Kelello ea dijithale e sebetsang, e tšepahalang, e fumanehang, e hohelang, le e theko e tlaase sesebelisoa sa skrine bakeng sa ts'ebeliso ea tleliniki e batloa ka potlako.

 

Morero: Ho lekola ts'ebeliso ea kliniki ea tlhahlobo ea memori ea MemTrax bakeng sa ho lemoha kapele ho holofala ha kelello sehlopheng sa Machaena.

 

Mekhoa: MemTrax ea metsotso e 2.5 le Montreal Kelo ea Kelello (MoCA) e entsoe ke ba 50 ba fumanoeng ba le boemong bo botle ba kelello (CON), bofokoli bo fokolang ba 50 ka lebaka la AD (MCI-AD), le baithaopi ba 50 ba Alzheimer's (AD). Peresente ea likarabelo tse nepahetseng (MTx-% C), nako ea karabelo e bolelang (MTx-RT), le lintlha tse kopaneng (MTx-Cp) tsa MemTrax le lintlha tsa MoCA li ile tsa hlahlobjoa ha ho bapisoa 'me ha hlahisoa li-curve tsa moamoheli (ROC).

 

Results: Litlhahlobo tse ngata tsa linear regression li bonts'itse MTx-% C, MTx-Cp, le lintlha tsa MoCA li ne li le tlase haholo ho MCI-AD khahlano le CON le ho AD khahlano le lihlopha tsa MCI-AD (tsohle tse nang le p≤0.001). Bakeng sa phapang ea MCI-AD ho tloha CON, MTx-% C cutoff e ntlafalitsoeng ea 81% e ne e na le 72% sensitivity le 84% e ikhethang e nang le sebaka se tlas'a curve (AUC) ea 0.839, athe lintlha tsa MoCA tsa 23 li ne li e-na le 54% sensitivity. le 86% e ikhethang e nang le AUC ea 0.740. Bakeng sa phapang ea AD ho MCI-AD, MTx-Cp ea 43.0 e ne e na le 70% ea kutlo le 82% e ikhethang e nang le AUC ea 0.799, athe lintlha tsa MoCA tsa 20 li ne li na le 84% sensitivity le 62% e ikhethang ka AUC ea 0.767.

 

fihlela qeto ena: MemTrax e khona ho bona ka nepo li-MCI le AD tse fumanoeng ke bongaka ka nepo ho bapisoa le MoCA e ipapisitseng le li-AUC ho sehlopha sa Machaena. Ho sebetsa ha MemTrax Memory Test ho thehiloe.

 

Keywords: Lefu la Alzheimer; sesebediswa sa kelo ya kelello; paradigm e tsoelang pele ea kananelo; bokooa ba kelello bo bobebe.

teko ea mohopolo, teko ea 'dementia', teko ea tahlehelo ea mohopolo, teko ea ho lahleheloa ke mohopolo oa nakoana
Lingaka tsa lipatlisiso tsa lefu la Alzheimer le 'dementia'

J. Wesson Ashford MD,
Ph.D.

E ngotse lingoliloeng tse fetang 160
on Lefu la Alzheimer 'me 10
ho bontsha katleho
ea MemTrax

Lefapha la Psychiatry &
Boitšoaro Sciences, Stanford
University

Motsamaisi, Mafu a Amanang le Ntoa le
Setsi sa Thuto ea Kotsi Palo
Khampase ea Alto ea VA Palo Alto

Ngaka Xianbo Zhou
Pharmaceutical Executive at
SJN Biomed

Lilemo tse 27 tsa lipatlisiso
phihlelo ea Biochem
Motsamaisi Kakaretso oa SJN
Biomed

Moprofesa le Mothehi
Motsamaisi oa Setsi sa
Maloetse a Alzheimer

Patlisiso ea Washington
Setsi sa Patlisiso ea Bongaka