Tataiso ea 2023 ea Epithalon

Lipatlisiso li bontša hore Epitalon, e atisang ho ngoloa Epithalone, ke analoge ea maiketsetso ea Epithalamin, polypeptide e hlahisoang ke pineal gland. Haeba u thahasella ho ithuta haholoanyane ka peptide ena, tsoela pele ho bala tataiso ea 2023 ea Epitalon peptide.

Moprofesa Vladimir Khavinson oa Russia o fumane tšibollo ea pele ea Epitalon peptide lilemong tse ngata tse fetileng[i]. O ile a leka litoeba ka lilemo tse 35 ho ithuta haholoanyane ka tšebetso ea Epitalon.

Lipatlisiso li bontša hore mosebetsi oa mantlha oa Epitalon ke ho matlafatsa maemo a tlhaho a telomerase. Telomerase ke enzyme ea endo native e thusang ho ikatisa ha lisele tsa telomere, li-endcaps tsa DNA. Ka lehlakoreng le leng, mokhoa ona o khothalletsa ho ikatisa ha DNA, e leng ntho e hlokahalang bakeng sa ho hlahisa lisele tse ncha le ho nchafatsoa ha tse hōlileng, ho latela liphuputso tsa phuputso.

Lipatlisiso li fana ka maikutlo a hore tlhahiso ea telomerase e phahame ho litoeba tse nyenyane ha li bapisoa le liphoofolo tse hōlileng. Li boetse li etsa li-telomere tse telele, tse ntlafatsang bophelo bo botle ba lisele le ho ikatisa.

Tlhahiso ea telomerase e fokotseha ha lilemo tsa litoeba li ntse li hōla, e leng se fokotsang ho ata ha lisele. Mona ke ha Epitalon e sebetsa, joalo ka ha ho bonts'itsoe ke lithuto tsa bongaka.

Epitalon e bapala mosebetsi ofe?

Epitalon e sebetsa joang? Boithuto ba liphoofolo bo bontšitse katleho ea eona ho lekanyetseng sekhahla sa metabolism, ho eketsa kutloelo-bohloko ea hypothalamic, ho boloka tšebetso ea anterior pituitary, le ho laola maemo a melatonin.

Lipatlisiso li senola hore DNA e khubung ea sele ka ’ngoe e meloho e ’meli; ka hona sebōpuoa se seng le se seng se nang le Epithalon peptide[ii] se fapane ka liphatsa tsa lefutso. Li-telomere li ka fumanoa qetellong ea likhoele tsa DNA. Li boloka tatellano ea tatellano ea DNA ka ho hanyetsa ho khutsufatsoa ha li-chromosome ka karolo e 'ngoe le e' ngoe ea lisele, ho latela liphuputso tsa bongaka.

Lipatlisiso li fana ka maikutlo a hore li-telomere tsa sele ka 'ngoe li khutsufala ka lebaka la ho ikatisa ho sa phethahalang ho etsahalang nako le nako ha lisele li arohana. 

Liphuputso tse 'maloa li amahantse khutsufatso ena le mafu a fapaneng a amanang le lilemo, ho kenyelletsa lefu la pelo le lefu la pele ho nako ho litoeba.

Ho ea ka liphuputso tsa lipatlisiso, palo e phahameng ea Epitalon e 'nile ea bitsoa "seliba sa bocha" ka lebaka la phello e ntle bophelong bo botle le nako ea bophelo.

Liphello tsa ho sebelisa Epitalon

Epitalon ke k'hemik'hale eo, ho ea ka lithuto tse 'maloa[iii] e entsoeng ho liphoofolo le litoeba, e tšoana le' mele oa mouse. Tshebetso ena e tsosolosa nako ea cellular ea likokoana-hloko, e lumellang lisele tse senyehileng hore li fole le ho tsosolosa mosebetsi o tloaelehileng oa setho.

Lilemong tse 'maloa tse fetileng, bo-rasaense ba Russia ba sibollotse lintho tse ngata tse amanang le Epithalon. Ka mohlala, bo-rasaense ba fumane hore e ka tsosolosa tlhahiso ea lisele tsa telomerase. Ho phaella moo, ba utloisisa hore e ka tsosolosa 'mele ka kakaretso' me ea ntlafatsa bophelo bo botle. Ba fumane hore e ka fetola botsofali ka ho shebana le sesosa sa eona lithutong tsa lipatlisiso.

Melemo ea Epitalon Peptide

Liphuputso li bontša hore Epitalon e na le melemo e mengata. Melemo e ntle ea bophelo bo botle e bonoang lithutong tsa liphoofolo ho sebelisoa Epitalon peptide ke e latelang:

• E lelefatsa bophelo ba litoeba.
• E thusa ho boloka liphoofolo li se na maemo a ho senyeha, ho kenyelletsa le lefu la Alzheimer, lefu la pelo le mofetše
• E eketsa boleng ba boroko.
• Bophelo bo botle ba letlalo
• Liphello ho matla a lisele tsa mesifa
• E eketsa sekhahla sa ho hlaphoheloa
• E fokotsa lipid peroxidation le tlhahiso ea ROS
• Ho phahamisa moeli oa khatello ea maikutlo
• E boloka palo e tsitsitseng ea melatonin ho litoeba

Ho hlokahala boithuto bo eketsehileng ba protheine ena ho ithuta litlamorao tsa eona tse felletseng. Leha ho le joalo, ho seo bafuputsi ba ithutileng sona ka Epithalon, ho bonahala eka haufinyane e tla fumaneha ho phekola le ho phekola mathata a mangata a bophelo bo botle. Ho makatsang ke hore, bafuputsi ba na le tšepo e kholo ea bokhoni ba Epitalon joalo ka kalafo le thibelo ea mofetše.

Mona, re tla hlahloba katleho le ts'ebeliso ea Epitalon peptide ka botlalo hore o tsebe ho etsa qeto ea hore na o tla e kenyelletsa lithutong tsa hau tsa lipatlisiso.

Thepa e Sebetsang e Khahlanong le Botsofali ea Epitalon

Biopeptide Epitalon e bontšitsoe ho atolosa bophelo ba likhoto ka 25% phuputsong e bitsoang "Theory neuroendocrine ea botsofali le boloetse bo fokolang," e ngotsoeng ke Moprofesa Vladimir Dilmice le Dr. Ward Dean ka 1992.

Liphuputso tse ngata tse lateloang ke Mopresidente St. Petersburg Institute of Bio-regulation le Moprofesa Vladimir Khavinson li netefalitse liphetho tsena tsa pele.

Bokhoni ba Epitalon ba ho theha maqhama a peptide lipakeng tsa li-amino acid tse ngata, joalo ka ha bo fumanoe ke bo-ramahlale bana, bo kenya letsoho ho litlamorao tsa nako e telele tsa bophelo. Ho ea ka liphuputso tsa lipatlisiso, e ka boela ea thibela ho hōla ha hlahala le ho eketsa ts'ebetso ea boko.

Khavinson o fumane, ho litoeba, hore biopeptides e matlafalitse tšebetso ea 'mele haholo le ho theola lefu ka hoo e ka bang 50% kamora lilemo tse 15 tsa tlhahlobo ea bongaka.

O boetse a fana ka bopaki ba hore litšebelisano lipakeng tsa Epithalon biopeptides le DNA li ka laola mesebetsi ea bohlokoa ea liphatsa tsa lefutso, ka ho lelefatsa nako ea bophelo.

Liphuputso li bontša hore Epitalon e ile ea atolosa bophelo ba litoeba ha e bapisoa le liphoofolo tse phekoloang ka placebo ho tloha ha li le likhoeli tse tharo ho fihlela lefung. Ho ea ka liphetho tsa lipatlisiso, ho senyeha ha chromosomal liseleng tsa moko oa masapo ho ile ha fokotseha ka tsela e tšoanang ka mor'a phekolo ea Epitalon. Litoeba tse phekoloang ka Epitalon le tsona li ne li sa bontše matšoao a ho ba le leukemia. Liphuputso tsa phuputso, tse nkiloeng ka kakaretso, li bontša hore peptide ena e na le tšusumetso e kholo ea ho thibela botsofali 'me e ka sebelisoa ka mokhoa o sireletsehileng ka ho sa feleng.

Lithuto tse 'maloa tsa liphoofolo li tiisa litla-morao tse latelang tsa Epitalon:

• Cortisol le melatonin synthesis e lieha le lilemo litšoeneng, e thusang ho boloka morethetho o tsitsitseng oa cortisol.
• Mekhoa ea ho ikatisa ea likhoto e ile ea sireletsoa hore e se ke ea tsoa kotsi, ’me ho holofala ho ile ha lokisoa.
• Sebopeho sa retina se lula se tiile ho sa tsotellehe tsoelo-pele ea lefu lena ho retinitis pigmentosa.
• Likhoto tse nang le mofetše oa mala li ile tsa fokotseha butle.

Tšusumetso ho Letlalo 

Liphuputso tsa liphoofolo li senotse hore ntle le thepa ea eona e thibelang botsofali, Epitalon e boetse e ntlafatsa bophelo ba letlalo.

Ho ea ka lipatlisiso tsa Dr. Khavinson, Epithalon e ka 'na ea susumetsa lisele[iv] tse ikarabellang ho lokisa le ho boloka matrix a extracellular a bolokang letlalo le phetse hantle le le lenyenyane. Collagen le elastin ke linaleli tse peli tse khahlanong le botsofali ka har'a matrix a extracellular.

Liphuputso li bontša hore litlolo tse ngata tse thibelang botsofali li tšepisa ho matlafatsa collagen letlalong, empa ke Epitalon feela ea etsang joalo. Epithalon e kena liseleng 'me e susumelletsa ho atolosoa le ho hōla ha fibroblasts e ikarabellang bakeng sa ho hlahisa collagen le liprotheine tse ling. Ka lebaka leo, sena se khothalletsa ntlafatso ea letlalo le phetseng hantle, ho latela liphuputso tsa lipatlisiso.

Liteko li bontša hore, leha ho le joalo, Epithalon peptide e sebetsa khahlanong le liphello tsa botsofali ho feta seo motho a se bonang. Boloetse, tšoaetso, le kotsi ke lintho tseo e ka itšireletsang khahlanong le tsona. Letlalo le tsofetseng le omella, le senyeha habonolo, 'me le atisa ho taboha. Joalokaha liteko tsa kliniki li bontša, ho sebelisa Epitalon letlalong ho ka thibela litla-morao tse joalo.

Phekolo ea Retinitis Pigmentosa 

Melamu e ka har'a retina e senngoa ke lefu le fokolisang le tsejoang e le retinitis pigmentosa. Ha khanya e otla retina, e etsa hore ho tsoe melaetsa ea lik’hemik’hale ka lithupa. Epitalon e ile ea bontšoa ho fokotsa tšenyo e senyang ea retina e bakoang ke lefu lena lipatlisisong tsa bongaka.

Epitalon e ntlafatsa ts'ebetso ea retina litekong tsa litoeba ka ho emisa ho senyeha ha sele le ho boloka sebopeho sa molamu, joalo ka lithuto tsa lipatlisiso.

Lipatlisiso li fana ka maikutlo a hore Epitalon ke phekolo e atlehileng bakeng sa retinitis pigmentosa lipatlisisong tse amang litoeba le likhoto. Leha ho le joalo, ho hlokahala boithuto bo eketsehileng ho netefatsa liphetho tsena. Mona u ka khona reka li-peptide inthaneteng.

[I] Anisimov, Vladimir N., le Vladimir Kh. Khavinson. "Peptide Bioregulation ea Botsofali: Liphetho le Melemo." Biogerontology 11, no. 2 (October 15, 2009): 139-149. doi:10.1007/s10522-009-9249-8.

[ii] Frolov, DS, DA Sibarov, le AB Vol'nova. "Ketso e Fetohileng ea Motlakase e Fumanetsoeng ho Rat Motor Neocortex ka mor'a Infusions ea Intranasal Epitalon." PsychEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., ... Sinjari, B. (2020). AEDG Peptide (Epitalon) E Stimulates Gene Expression le Protein Synthesis nakong ea Neurogenesis: Mokhoa o ka khonehang oa Epigenetic. Limolek'hule, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, NI, NS Linkova, AN Zhekalov, AO Orlova, GA Ryzhak, le V. Kh. Khavinson. "Li-Peptide Tse Khutšoane li Tsosolosa Tsosoloso ea Lisele Letlalo Nakong ea Botsofali." Tsoelo-pele ho Gerontology 5, No. 3 (Phupu 2015): 176-179. Doi: 10.1134 / s2079057015030054.

[v] Korkushko, OV, V. Kh. Khavinson, VB Shatilo, le LV Magdich. "Phello ea Peptide Tokisetso ea Epithalamin ho Circadian Rhythm ea Epiphyseal Melatonin-E Hlahisa Mosebetsi ho Batho ba Hōlileng." Bulletin of Experimental Biology and Medicine 137, no. 4 (April 2004): 389–391. doi:10.1023/b:bebm.0000035139.31138.bf.