CUDURKA ALZHEIMER: CUDURKA NEURON MIYAY U SOO HORSEEDA INAY HOOS U DHACDO AXOOYINKA NEUROFIBRILLARY?
Wargeyska Caafimaadka ee New England, Vol. 313, bogga 388-389, 1985
CUDURKA ALZHEIMER: CUDURKA NEURON MIYAY U SOO HORSEEDA INAY HOOS U DHACDO AXOOYINKA NEUROFIBRILLARY?
Ku socota Tifaftiraha: Gajdusek wuxuu qiyaasayaa in carqaladeynta neurofilaments ay tahay saldhigga dhowr cudur oo asaasaqa ah (arrinta 14-ka Maarso). 1 Si loo sharaxo sababta qaar ka mid ah neerfayaasha maskaxda ay u saameeyaan kuwa kale, wuxuu soo jeedinayaa in unugyada leh geedo waaweyn oo axonal ah, sababtoo ah baahida weyn ee gaadiidka axonal, ayaa si gaar ah ugu nugul dhaawaca axoskeletal. Mala-awaalka Gajduseks waa mid soo jiidasho leh laakiin ku guul daraystay in uu xisaabiyo aragtida ah in neerfayaasha otor-ka ee waaweyn ay si yar u saameeyeen cudurka Alzheimers.
Waxaan soo jeedinaynaa in balaastikada unugyada iyo sidoo kale cabbirka geedka axonal ay ku soo rogi karaan dalabaadka gaadiidka axonal. Balaastiga unugyada neerfaha ayaa la xiriira arrimo kala duwan oo trophic ah,2 kuwaas oo qaarkood ku lug leeyihiin gaadiidka axonal. Tusaalaha muhiimka ah waa biqilka lagu arkay septal norepinephrine terminals,3 malaha waxaa weheliya qulqulka badan ee neurofilaments cusub.
Neurons oo muujinaya heer sare oo balaastig ah ayaa laga yaabaa inay sameeyaan substrate-ka xusuusta iyo barashada; Labaduba waxay ku naafo yihiin cudurka Alzheimers. Wadooyinka Norepinephrine waxa lala xidhiidhiyay barashada abaalgudka,4 iyo unugyada norephinephrine ee ceruleus locus waa la burburiyaa xaaladaha qaarkood Cudurka Alzheimers.5 Alzheimers degeneration sidoo kale waxay dhaawacdaa meesha asalka ah ee unugyada serotonin ee maskaxda dhexe ee raphe,6 iyo serotonin ayaa la soo jeediyay dhexdhexaadiyaha qaboojinta caadiga ah.7 Wadooyinka Acetylcholine ee ka soo baxa nukleus basalis ee Meynert ilaa kiliyaha ayaa laga yaabaa inay door yeeshaan. ee latchkey ee xasuusta adag kaydinta iyo dib u soo celinta,8.9 iyo sida la wada ogsoon yahay, cudurka Alzheimers wuxuu la xiriiraa luminta unugyada unugyada iyo sidoo kale enzymeskooda. 10 labaduba waxay door weyn ka ciyaaraan xusuusta.11 Intaa waxaa dheer, neurofibrillary degeneration wuxuu ku dhacaa si xulashada neerfayaasha leh axon ee isku xira hippocampus iyo kortexka entorhinal. balaastig heer sare ah, xumaantoodu waxay taageertaa fikradda ah in unugyada muujinaya balaastiga la taaban karo ay u nugul yihiin carqaladeynta neurofibrillary.
Burburinta habka gaabiska axonal-gaadiidka ee neurons-ka leh heer sare oo balaastiig ah waxay u horseedi kartaa cillad xusuusta baahsan, calaamadda asaasiga ah waallida iyadoon loo eegin sababta. Cilad-darradan axonal-filament waxay ku siin kartaa saldhigga micropathological ee xiriirkii hore loo dhajiyay ee u dhexeeya diathesis microtubular iyo nooca Alzheimer. waallida 15,16 iyo isku xidh-hoosaadka cudurrada asaasaqa.
J. Wesson Ashford, MD, Ph.D.
Lissy Jarvik, MD, Ph.D.
Machadka Neuropsychiatric UCLA
Los Angeles, CA 90024