Ngingakunciphisa kanjani ukuqhubeka kwesifo i-Alzheimer's?

Kuleli sonto siqhubeka nengxoxo yethu noDkt. Ashford futhi uyachaza ukuthi kungani umkhakha wocwaningo lwe-Alzheimer ungazange ukhiqize kakhulu nokuthi kungani “usendleleni edukile ngokuphelele.” UDkt. Ashford ufuna ukukufundisa nokuthi ungasivikela kanjani isifo i-Alzheimer's kanye nokuwohloka komqondo. Ukuwohloka komqondo kungagwemeka futhi kungcono kakhulu ukuqonda nokuqeda izici eziyingozi okungenzeka ubhekane nazo. Funda njengoba siqhubeka nengxoxo yethu ne-Alzheimer's Speaks Radio.

Lori:

UDkt. Ashford ungasitshela isimo solunye ucwaningo lwamanje lwesifo i-Alzheimer kanye nokuwohloka komqondo laphaya. Ngiyazi ukuthi uke washo ukuthi ubucabanga ukuthi sizokwazi ukukunqanda lokhu hhayi nje ukukwelapha kodwa ukukuvimba. Ingabe sikhona isifundo esisodwa noma ezimbili ozijabulele eziqhubekayo lapho?

Ucwaningo lwe-Alzheimer's

UDkt. Ashford :

I-Aggravated igama elingcono kakhulu lomuzwa wami mayelana nocwaningo lwe-Alzheimer's. Bengilokhu ngisensimini kusukela ngo-1978 futhi benginethemba lokuthi ngabe sesiyiqedile yonke le nto eminyakeni eyi-10 noma eyi-15 edlule. Sisabhekene nayo. Kune-athikili ebikhona yomibili Nature futhi IScientific America, omagazini abahlonishwa kakhulu, ngoJuni ka-2014 ababekhuluma ngokuthi ucwaningo lwaluqhubeka kuphi emkhakheni wesifo i-Alzheimer's. Kusukela ngo-1994 umkhakha wesifo i-Alzheimer ubulokhu uphethwe into ebizwa ngokuthi i-Beta-amyloid Hypothesis, umcabango ukuthi i-Beta-amyloid iyimbangela yesifo i-Alzheimer's. Kwakukhona izingcezu ezimbalwa zobufakazi obuqinile obukhomba kule ndlela kodwa azizange zibonise ukuthi i-Beta-amyloid empeleni yayiyimbangela yangempela, noma kunjalo, insimu yayibuswe yile mbono yokubheka indlela yokuvimbela ukuthuthukiswa I-Beta-amyloid. Okwaziwa manje njengephrotheni evamile ebuchosheni, enye yamaprotheni aphendulwe kakhulu ebuchosheni. Ukuzama ukukuqeda kufana nokuthi “Kulungile, omunye uyopha. Masiqede elithwala umoya-mpilo okungase kunqande ukopha.” Kube yisiqondiso esidukile ngokuphelele. Cishe ngesikhathi esifanayo ekuqaleni kwawo-1990 kwatholakala ukuthi kunesici sofuzo esihlobene nesifo i-Alzheimer's, manje akekho othanda ukubhekana nezakhi zofuzo ikakhulukazi uma zizobatshela ukuthi maningi amathuba okuthola isifo i-Alzheimer's. Kunofuzo olwatholakala eminyakeni engu-20 edlule olubizwa ngokuthi I-Apolipoprotein E (APOE), futhi ngithemba ukuthi inkambu izobuyela emuva ekuqondeni isakhi sofuzo se-APOE nokuthi yenzani.

Inkinga ukuthi iphrotheni yangaphambili ye-Amyloid ihamba ngezindlela ezimbili ezihlukene ingena ekwakheni ama-synapse amasha, okuwukuxhumana ebuchosheni, noma asuse ama-synapse. Lokhu kuhambisana kahle nalokho okusanda kuwina umklomelo kaNobel namuhla ukuthi kukhona ukwakheka kwepulasitiki okungaguquki nokushintsha njalo ukuxhumana ebuchosheni okuhlaselwa yi-Alzheimer's. Uma sikuqonda lokho nokuthi isici sofuzo sihlobene kanjani nalokho kuhlasela ngicabanga ukuthi sizokwazi ukuqeda isifo i-Alzheimer's. Isihloko sikaDkt Bredesen ku Ukuguga libala izinto ezingaba ngu-30 ezihlukene ebezibalulekile esifweni i-Alzheimer's futhi lezi wuhlobo lwezinto okufanele sizibheke ukuze sibone zonke izinto ezahlukene esingayenza ukuze sigweme isifo i-Alzheimer's. Ake ngenze isibonelo esisodwa: Akucaci ukuthi isifo sikashukela sihlobene nesifo i-Alzheimer's kodwa sihlobene nokuwohloka komqondo, sibangela isifo semithambo yegazi kanye nokushaywa unhlangothi okuncane okuyimbangela yesibili ehamba phambili yokuwohloka komqondo. Kunoma ikuphi ufuna ukuvikela isifo sikashukela futhi lolu hlobo lwesifo sikashukela sohlobo lwesibili luyagwemeka ngokwenza izinto ezinzima kakhulu njengokuzivocavoca ngokwanele, ukungakhuluphali, nokudla ukudla okunempilo. Khona manjalo lezo kungaba yizinto ezingcono kakhulu okufanele uzicabangele ukuze kuvinjelwe isifo i-Alzheimer's noma okungenani ukuwohloka komqondo.

Ungasivikela Kanjani Isifo I-Alzheimer's

Yidla ukudla okunomsoco, vivinya umzimba ngokwanele, qiniseka ukuthi awusiphumi isikali endaweni engafanele. Okunye okubalulekile esikubonile ukuthi abantu abanemfundo ethe xaxa banesifo i-Alzheimer's esincane, sikuthakasela kakhulu ukukhuthaza abantu ukuthi bathole imfundo enhle futhi baqhubeke nokufunda impilo ende, lezo ngezinye zezinto ezilula kakhulu. Ungangena kwezinye izinto ezinjengokulawula umfutho wegazi lakho, ukubonana nodokotela wakho njalo, ukubuka i-vitamin b12 kanye ne-vitamin D kuye kwabonakala kubaluleke kakhulu. Kunochungechunge oluphelele lwezinto ezinjengalezi, kuzokhula kubaluleke kakhulu ukuthi abantu bazi ngalezi zinto ukuvimbela izici ezithile eziyingozi. Esinye sezici ezinkulu ezibeka engcupheni yesifo i-Alzheimer's ukuhlukumezeka ekhanda. Gqoka ibhande lapho ugibele imoto yakho, uma uzogibela ibhayisikili, okuyinto enhle kakhulu kuwe, gqoka umakalabha lapho ugibele ibhayisikili lakho! Kunezinhlobonhlobo zezinto ezilula, njengoba singakwazi ukuzibala kakhulu, sifundise abantu ukuthi benzeni. Kuvele ukuthi kunobufakazi bakamuva obuveza ukuthi izibalo ze-Alzheimer ziyehla njengoba abantu belandela lezi zeluleko ezinhle zezempilo kodwa sidinga ukuthi zehle ngokuthi wonke umuntu alandele la macebiso amahle ezempilo.

UDkt. Ashford uncoma ukuthi uthathe I-MemTrax kanye ngesonto noma kanye ngenyanga ukuze uthole ukuqonda okujwayelekile ngempilo yobuchopho bakho. Thatha i Ukuhlolwa kwememori ye-MemTrax ukuhlonza izimpawu zokuqala zokulahlekelwa inkumbulo ezivame ukuhlotshaniswa nazo Isifo i-Alzheimer.