Umhlahlandlela wango-2023 we-Epithalon

Ucwaningo lubonisa ukuthi i-Epitalon, evame ukupelwa ngokuthi i-Epithalone, iyi-analog yokwenziwa ye-Epithalamin, i-polypeptide ekhiqizwa ku-pineal gland. Uma ungathanda ukufunda okwengeziwe ngale peptide, qhubeka ufunda umhlahlandlela ka-2023 we-Epitalon peptide.

USolwazi Vladimir Khavinson waseRussia wenza ukutholwa kokuqala kwe-Epitalon peptide eminyakeni eminingi edlule[i]. Uzame amagundane iminyaka engu-35 ukuze afunde kabanzi ngomsebenzi we-Epitalon.

Ucwaningo lubonisa ukuthi umsebenzi oyinhloko we-Epitalon ukukhulisa amazinga e-endogenous e-telomerase. I-Telomerase iyi-enzyme engapheli eyenza kube lula ukuphindaphinda kwamaselula ama-telomere, ama-endcaps e-DNA. Le nqubo, yona, ikhuthaza ukuphindaphinda kwe-DNA, okudingekayo ukuze kwakhiwe amangqamuzana amasha nokuvuselela amadala, njengokutholwe kocwaningo.

Ucwaningo luphakamisa ukuthi ukukhiqizwa kwe-telomerase kuphezulu kumagundane amancane uma kuqhathaniswa nezilwane ezindala. Baphinde badale ama-telomere amade, athuthukisa impilo yeselula nokuphindaphinda.

Ukukhiqizwa kwe-telomerase kuyehla ngokuya ngeminyaka kumagundane, okunciphisa ukuphindaphindeka kwamaseli. Nakhu lapho i-Epitalon isiza khona, njengoba kuboniswa izifundo zomtholampilo.

Imuphi umsebenzi odlalwa yi-Epitalon?

I-Epitalon isebenza kanjani? Ucwaningo lwezilwane lubonise ukusebenza kahle kwayo ekulinganiseni izinga lokugayeka kokudla, okwandisa ukuzwela kwe-hypothalamic, ukugcina ukusebenza kwe-pituitary yangaphambili, nokulawula amazinga e-melatonin.

Ucwaningo lwembula ukuthi i-DNA kuyi-nucleus yengqamuzana ngalinye inemicu emibili; yingakho isidalwa ngasinye esine-Epithalon peptide[ii] sihlukile ngokofuzo. Ama-telomere angatholakala ekugcineni kwezintambo ze-DNA. Zilondoloza ubuqotho bokulandelana kwe-DNA ngokuphikisana nokufinyezwa kwama-chromosome ngokuhlukana kweseli ngakunye, njengokutholwe komtholampilo.

Ucwaningo lusikisela ukuthi ama-telomere eseli ngalinye aba mafushane ngenxa yokuphindaphinda okungaphelele okwenzeka njalo lapho amaseli ehlukana. 

Ucwaningo oluningana luhlobanise lokhu kufinyezwa kwezifo ezahlukahlukene ezihlobene nobudala, okuhlanganisa nesifo senhliziyo kanye nokufa ngaphambi kwesikhathi kumagundane.

Ngokusho kokutholwe kocwaningo, ukugxila okuphezulu kwe-Epitalon kuye kwabizwa ngokuthi "umthombo wobusha" ngenxa yethonya elihle empilweni nasekuphileni.

Imiphumela Yokusebenzisa i-Epitalon

I-Epitalon ikhemikhali okuthi, ngokwezifundo ezimbalwa[iii] ezenziwa ezilwaneni namagundane, ifane ngokomzimba naleyo ekhiqizwa umzimba wegundane. Le nqubo imisa kabusha iwashi lebhayoloji yeselula, ivumela izicubu ezilimele ukuba zelaphe futhi zibuyisele ukusebenza kwesitho esijwayelekile.

Eminyakeni embalwa edlule, ososayensi baseRussia baye bathola okuningi okuhlobene ne-Epithalon. Ngokwesibonelo, ososayensi bathole ukuthi ingavuselela ukukhiqizwa kwamangqamuzana e-telomerase. Ngaphezu kwalokho, bayaqonda ukuthi kungase kuvuselele umzimba wonke futhi kuthuthukise impilo. Bathole ukuthi ingakwazi nokuhlehlisa ukuguga ngokukhomba imbangela yako ezifundweni zocwaningo.

Izinzuzo ze-Epitalon Peptide

Ucwaningo lubonisa ukuthi i-Epitalon inezinzuzo eziningana. Izinzuzo ezinhle empilweni eziye zabonwa ezifundweni zezilwane kusetshenziswa i-Epitalon peptide zimi kanje:

  • Kwenza isikhathi sokuphila kwamagundane.
  • Isiza ukugcina izilwane zingenazo izimo eziwohlokayo, okuhlanganisa i-Alzheimer's, isifo senhliziyo, nomdlavuza
  • Yandisa ikhwalithi yokulala.
  • Impilo yesikhumba ethuthukisiwe
  • Imithelela emandleni amaseli emisipha
  • Inyusa izinga lokululama
  • Yehlisa i-lipid peroxidation kanye nokukhiqizwa kwe-ROS
  • Ukuphakamisa umkhawulo wokucindezeleka ngokomzwelo
  • Igcina amanani angashintshi e-melatonin kumagundane

Kudingeka ucwaningo olwengeziwe lwale phrotheni ukuze ufunde imiphumela yawo egcwele. Kulokho abacwaningi abaye bakufunda nge-Epithalon, nokho, kubonakala sengathi izotholakala maduze ukwelapha nokwelapha izinkinga eziningi zempilo. Ngokumangazayo, abacwaningi banethemba elikhulu ngekhono le-Epitalon njengokwelashwa nokuvimbela umdlavuza.

Lapha, sizohlola ukusebenza kahle nokusebenza kwe-Epitalon peptide ngemininingwane eyengeziwe ukuze unqume ukuthi uyayifaka yini ocwaningweni lwakho.

Izakhiwo Eziphumelelayo Zokulwa Nokuguga ze-Epitalon

I-Biopeptide Epitalon iboniswe ukwandisa ukuphila kwamagundane ngo-25% ocwaningweni olubizwa ngokuthi "I-neuroendocrine theory of aging and degenerative disease," ebhalwe nguProfesa Vladimir Dilmice noDkt Ward Dean ngo-1992.

Uphenyo oluningi lokulandela olwenziwa nguMongameli St. Petersburg Institute of Bio-regulation kanye noProfesa Vladimir Khavinson baqinisekisa le miphumela yokuqala.

Amandla e-Epitalon okwenza ukuxhumana kwe-peptide phakathi kwama-amino acid amaningi, njengoba kutholwe yilaba sosayensi, kunomthelela emiphumeleni enwetshiwe yokuphila isikhathi eside. Ngokusho kokutholwe kocwaningo, kungase futhi kuvimbele ukukhula kwesimila futhi kwandise umsebenzi wobuchopho.

U-Khavinson uthole, kumagundane, ukuthi ama-biopeptide athuthukisa ngokuphawulekayo ukusebenza komzimba futhi ehlisa ukufa kwabantu cishe ngo-50% ngemva kweminyaka engu-15 yokuqashwa komtholampilo.

Uphinde wanikeza ubufakazi bokuthi ukusebenzisana phakathi kwe-Epithalon biopeptides ne-DNA kungase kulawule imisebenzi ebalulekile yofuzo, kunwebe ngempumelelo isikhathi sokuphila.

Ucwaningo lukhombisa ukuthi i-Epitalon yandisa izimpilo zamagundane uma iqhathaniswa nezilwane ezilashwe nge-placebo kusukela eneminyaka eyizinyanga ezintathu kuze kube sekufeni. Ngokwemiphumela yocwaningo, ukuphazamiseka kwe-chromosomal kumaseli omnkantsha kwancipha ngokufanayo ngemva kokwelashwa nge-Epitalon. Amagundane alashwe nge-Epitalon nawo awazange akhombise izimpawu zokuthuthukisa i-leukemia. Okutholwe ocwaningweni, okuthathwe kukonke, kukhombisa ukuthi le peptide inomthelela omkhulu wokulwa nokuguga futhi ingasetshenziswa ngokuphepha unomphela.

Izifundo eziningana zezilwane ziqinisekisa imiphumela emibi elandelayo ye-Epitalon:

  • I-Cortisol ne-melatonin synthesis ihamba kancane ngokukhula kwezinkawu, okusiza ukugcina isigqi se-cortisol esiqinile.
  • Izimiso zokuzala zamagundane zazivikelekile ekulimaleni, futhi ukonakala kwalungiswa.
  • Isakhiwo se-retina sihlala sinjalo naphezu kokuqhubeka kwesifo ku-retinitis pigmentosa.
  • Amagundane anomdlavuza wamakholoni aba nokuncipha kokukhula.

Umthelela Esikhumbeni 

Ucwaningo lwezilwane luye lwembula ukuthi ngaphezu kwezakhiwo zayo zokulwa nokuguga, i-Epitalon ibuye ithuthukise impilo yesikhumba.

Ngokocwaningo lukaDkt. Khavinson, i-Epithalon ingase ikhuthaze amaseli[iv] aphethe ukulungisa nokugcina i-matrix engaphandle kweseli egcina isikhumba sinempilo futhi sisebasha. I-Collagen ne-elastin yizinkanyezi ezimbili ezimelene nokuguga ku-matrix engaphandle kweseli.

Ucwaningo lubonisa ukuthi izinto zokugcoba eziningi zokulwa nokuguga zithembisa ukuqinisa i-collagen esikhumbeni, kodwa yi-Epitalon kuphela eyenza lokho. I-Epithalon ingena emangqamuzaneni futhi ikhuthaze ukwanda nokuvuthwa kwama-fibroblasts anesibopho sokukhiqiza i-collagen namanye amaprotheni. Ngenxa yalokho, lokhu kukhuthaza ukuvuselelwa kwesikhumba okunempilo, ngokusho kwemiphumela yocwaningo.

Ukuhlola kubonisa ukuthi, nokho, i-Epithalon peptide iyasebenza ngokumelene nemiphumela yokuguga ngaphezu kwalokho okuhlangabezana neso. Izifo, ukutheleleka, nokulimala yizo zonke izinto engazivikela kuzo. Isikhumba esidala siba somile, sibe ntekenteke, futhi sijwayele ukudabuka. Njengoba izivivinyo zomtholampilo zibonisa, ukusebenzisa i-Epitalon esikhumbeni kungase kuvimbele imiphumela enjalo engemihle.

Ukwelashwa kwe-Retinitis Pigmentosa 

Izinduku ku-retina zibhujiswa ukugula okuwohlokayo okwaziwa ngokuthi i-retinitis pigmentosa. Lapho ukukhanya kungena ku-retina, kubangela ukukhululwa kwemiyalezo yamakhemikhali ngezinduku. I-Epitalon yaboniswa ukunciphisa ukulimala okuwohlokayo ku-retina okubangelwa ukuphazamiseka ophenyweni lomtholampilo.

I-Epitalon ithuthukisa ukusebenza kwe-retinal ekuhlolweni kwamagundane ngokumisa ukonakala kwamaseli nokugcina ukwakheka kwezinduku, njengokwezifundo zocwaningo.

Ucwaningo luphakamisa ukuthi i-Epitalon iwukwelapha okuphumelelayo kwe-retinitis pigmentosa ocwaningweni olubandakanya amagundane namagundane. Nokho, ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe le miphumela. Lapha ungakwazi thenga ama-peptides ku-inthanethi.

[i] Anisimov, Vladimir N., kanye noVladimir Kh. Khavinson. "I-Peptide Bioregulation of Aging: Imiphumela Namathemba." I-Biogerontology 11, no. 2 (Okthoba 15, 2009): 139–149. doi:10.1007/s10522-009-9249-8.

[ii] U-Frolov, DS, DA Sibarov, no-AB Vol'nova. "Umsebenzi Kagesi Oguquliwe Ozenzakalelayo Utholwe Ku-Rat Motor Neocortex ngemuva Kokufakwa Kwe-Intranasal Epitalon." I-PsycEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). I-AEDG Peptide (i-Epitalon) Ivuselela Ukuvezwa kweGene kanye ne-Protein Synthesis ngesikhathi se-Neurogenesis: I-Epigenetic Mechanism engenzeka. Ama-molecule, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, NI, NS Linkova, AN Zhekalov, AO Orlova, GA Ryzhak, kanye no-V. Kh. Khavinson. "Ama-Peptides Amafushane Akhuthaza Ukuvuselelwa Kweseli Esikhumbeni Ngesikhathi Sokuguga." Intuthuko ku-Gerontology 5, no. 3 (Julayi 2015): 176-179. doi: 10.1134 / s2079057015030054.

[v] Korkushko, OV, V. Kh. Khavinson, VB Shatilo, and LV Magdich. "Umthelela we-Peptide Preparation Epithalamin ku-Circadian Rhythm ye-Epiphyseal Melatonin-Producing Function Kubantu Asebekhulile." I-Bulletin of Experimental Biology and Medicine 137, no. 4 (April 2004): 389–391. doi:10.1023/b:bebm.0000035139.31138.bf.

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