Ukuba semthethweni kwe-MemTrax Ukuhlolwa kweMemori Uma kuqhathaniswa ne Ukuhlolwa Kokuqonda Okuqondwayo kweMontreal Ekutholeni Ukukhubazeka Kwengqondo Okumaphakathi kanye Nokuwohloka komqondo ngenxa yesifo i-Alzheimer's eqenjini laseShayina

 

Xiaolei Liu, Xinjie Chen , Xianbo Zhou , Yajun Shang, Fan Xu , Junyan Zhang, Jingfang He, Feng Zhao, Bo Du, Xuan Wang, Qi Zhang, Weishan Zhang, Michael F Bergeron, Tao Ding, J Wesson Ashford, Lianmei Zhong

• I-PMID: 33646151
• I-DOI: 10.3233/JAD-200936

abstract

 

Ingemuva: Ingqondo yedijithali evumelekile, ethembekile, efinyelelekayo, ehehayo, futhi ethengekayo ithuluzi lesikrini ukusetshenziswa emtholampilo kudingekile ngokuphuthumayo.

 

Injongo: Kuya hlola ukusetshenziswa komtholampilo kokuhlolwa kwenkumbulo ye-MemTrax ukuze kutholwe kusenesikhathi ukukhubazeka kwengqondo eqenjini lamaShayina.

 

Izindlela: I-MemTrax yemizuzu engu-2.5 kanye neMontreal Ukuhlola ingqondo (I-MoCA) yenziwe ngabangu-50 abaxilongwa ngokomtholampilo ngendlela evamile (CON), ukukhubazeka kwengqondo okuncane okungu-50 ngenxa ye-AD (MCI-AD), kanye nabahlanganyeli abangama-50 besifo se-Alzheimer (AD). Iphesenti lezimpendulo ezilungile (MTx-% C), isikhathi sokuphendula esimaphakathi (MTx-RT), kanye namaphuzu ayinhlanganisela (MTx-Cp) ye-MemTrax kanye nezikolo ze-MoCA ahlaziywa ngokuqhathaniswa futhi kwakhiqizwa amajika esici sokusebenza somamukeli (ROC).

 

Ezenye: Ukuhlaziywa kokuhlehla komugqa okuningi kubonise i-MTx-% C, MTx-Cp, kanye nesikolo se-MoCA bekuphansi kakhulu ku-MCI-AD uma kuqhathaniswa ne-CON kanye naku-AD uma kuqhathaniswa namaqembu e-MCI-AD (konke okuno-p≤0.001). Ukuze kuhlukaniswe i-MCI-AD kusukela ku-CON, i-MTx-% C cutoff elungiselelwe engu-81% ibe nokuzwela okungu-72% kanye nokucaciswa okungu-84% ngendawo engaphansi kwejika (AUC) engu-0.839, kuyilapho amaphuzu we-MoCA angu-23 abe nokuzwela okungu-54%. kanye nokucaciswa okungu-86% nge-AUC engu-0.740. Ukuze kuhlukaniswe i-AD ku-MCI-AD, i-MTx-Cp engu-43.0 ibe nokuzwela okungu-70% nokucaciswa okungu-82% nge-AUC engu-0.799, kuyilapho amaphuzu e-MoCA angu-20 ayenokuzwela okungu-84% nokucaciswa okungu-62% nge-AUC engu-0.767.

 

Isiphetho: I-MemTrax ingathola ngempumelelo kokubili okutholwe emtholampilo i-MCI ne-AD ngokunemba okungcono uma kuqhathaniswa ne-MoCA esekelwe kuma-AUC eqenjini lamaShayina. Ukufaneleka kokuhlolwa kweMemTrax Memory sekusunguliwe.

 

Amagama angukhiye: Isifo i-Alzheimer's; ithuluzi lokuhlola ingqondo; ipharadigm yomsebenzi wokuqashelwa okuqhubekayo; ukukhubazeka kwengqondo okuncane.