I-Alzheimer's Speaks Radio Interviews MemTrax : Ukuzitholela Umuntu Ngokuwohloka komqondo - Ingxenye 2
Ngesonto eledlule, kweyethu blog okuthunyelwe, siqale ingxoxo yethu ye-Alzheimer's Speaks Radio ngesethulo sikaDkt. Ashford, umsunguli we Ukuhlolwa kwe-MemTrax, kanye nombono ka-Lori La Bey kanye nomlando wakhe wokubhekana nesifo sokuwohloka komqondo. Kuleli sonto mina noDkt. Ashford sixoxa ngoBabamkhulu wethu owayenesifo i-Alzheimer futhi sabelana ngokuthi kwakunjani ukubhekana nalesi sifo esibulalayo. Kuleli sonto sizobhala ngaphezulu kwenhlolokhono futhi sinikeze ukuqonda okuwusizo ukusiza ukukhuthaza ucwaningo nokuqwashisa ngesifo i-Alzheimer's.
Ingxenye 2 : Ukuhlola Ukuhlolwa Kwe-MemTrax Nokuvama Kokuwohloka Komqondo
I-Lori:
Ngaphambi kokuthi singene emgqeni wethu wemibuzo ngifuna futhi ukwethula uCurtis Ashford, engikholwa ukuthi uyindodana yakho, futhi waba nentshisekelo yokuhlolwa kwengqondo njenge-undergraduate eCalifornia State University eSan Jose (Silicon Valley) lapho athweswa khona iziqu ngo-2011 Eminyakeni engu-3 edlule usebenze eduze ukuze athuthukise lo msebenzi olula wokuhlola ukuze ahlole izinguquko enkumbulweni esebenzisa inkundla yezokuxhumana, ikhompuyutha, nobuchwepheshe be-inthanethi ukuze azise futhi akhuthaze ukuhlola inkumbulo okuvamile nokungaguquki. UCurtis unentshisekelo yokugqugquzela ukutholwa kusenesikhathi kwezinguquko zenkumbulo ezingase zibonise ukuqala kwesifo i-Alzheimer's noma ukuba khona kwezinye izimbangela zokuphazamiseka kwengqondo. Njengamanje uhola iMemTrax ekuthuthukiseni uhlelo ukuhlola kwengqondo isofthiwe ezwelayo yokuhlola ukuqala kwangaphambi kwesikhathi kwezinguquko zenkumbulo kanye nokukhuthaza ukungenelela kusenesikhathi ngaphambi kokuthi kuthuthuke ukukhubazeka kokuthuthukiswa kwengqondo. Wamukelekile ke uCurtis, unjani namuhla?
UCurtis:
Sawubona Lori, siyabonga kakhulu ngokuba nathi namuhla!
I-Lori:
Hhayi-ke ngijabule nje, sekuphele unyaka manje ngizwa ngenkampani yenu futhi enye yezinto engifuna ukunibuza yona nobabili, ngizoqala ngoCurtis lapha. Ingabe uke wathinteka mathupha emndenini wakho noma umngane oseduze onokuwohloka komqondo, izethameli zethu zihlala zithanda ukuzwa uma kukhona okuncane komuntu siqu.
UCurtis:
Yebo, umkhulu wami empeleni, umkhulu wami uJohn wayekubi kakhulu. Ngangimncane impela, ngineminyaka engaba ngu-14 noma 15, njengoba eqala ukuwohloka. Ngangihlala naye, futhi kwakubuhlungu ngempela ngoba isikhathi ngasinye lapho ubuyela ekuvakasheni wayekhohlwa kancane ngawe noma ubaba wami noma akhohlwe igama lomunye umuntu. Ungakwazi nakanjani ukukuthatha isikhathi ngasinye futhi uyazi ukuthi kukhona okwenzekayo.
I-Lori:
Mmmh, yebo. UDkt. Ashford, kuthiwani ngawe, ngabe ubaba wakho owayenokuwohloka komqondo noma kwakungalelo cala?
UDkt. Ashford:
Cha, kwakungubaba wami lowo.
Isithakazelo sami kulokhu sasivela ohlangothini oluhlukile, lapho ngiseBerkeley isithakazelo sami ngaphandle kwazo zonke ezombangazwe sasizama ukuphila phakade ngakho nganginesithakazelo kakhulu enqubweni yokuguga, nokuthi ngingayimisa kanjani. Njengoba ngangiqhubeka ngiwutadisha ngaqala ukubheka ubuchopho njengesitho esiyinhloko esilawula yonke into, futhi ngabona ukuthi ukuze ngiqonde inqubo yokuguga kwakuzodingeka ngiqonde indlela ubuchopho obulawula ngayo ukuguga. Njengoba isikhathi siqhubeka ngabona ukuthi ngangingeke ngikwazi ukumisa inqubo yokuguga, kwakuzodingeka ngiphile impilo engcono kakhulu engangingayiphila. Ngangisathanda izindlela zokuguga futhi kwavela ukuthi njengoba ngibheka inani labantu kanye nama-baby boomers, engiyilungu lawo, ukuguga, ziningi izinto esasingazenza ukuze sigweme ukufa; ungabhemi ugwayi, uphile impilo enempilo, ubophe amabhande ethu ezihlalo, futhi ubalekele izinkinga eziningi ezingakubangela ukuba ufe. Kodwa kwenzeka, lapho ngifunda izinto ngokwandayo, inkinga engathi sína kakhulu engayibona ibheke phambili kwakuyisifo i-Alzheimer's, futhi njengoba izingane ezikhulakhulile zikhula futhi zizinakekela kangcono futhi ziphila isikhathi eside nangaphezulu inkinga ye-Alzheimer's izoba yisifo se-Alzheimer's. inkinga ebhubhisa kakhulu yekhulu leminyaka.
Ngakho-ke ngaba nesithakazelo kusifo i-Alzheimer ngokombono Wezempilo Yomphakathi. Ngo-1978, ngaba umhlali wokuqala oyinhloko ophikweni lwezifo zengqondo e-UCLA futhi ngaqala ukubona ukuthi cishe ezi-2 kuzo zonke iziguli ezi-5 esizivumile zazingakwazi ukukhumbula okuthile. Ngangibacela ukuba bakhumbule amagama angu-5 futhi kusobala ukuthi noma ubani angakhumbula la mazwi alula, ngangibuya futhi ngithi yimaphi amagama engikucele ukuba uwakhumbule? Khona-ke abantu ababili kwabahlanu babengasakhumbuli nokuthi ngibacele ukuba bakhumbule amagama angu-2, futhi ngathi, “lokhu akunangqondo.” Ngangikade ngiyithanda kakhulu inkumbulo kakade, umeluleki wami kwakunguProfesa Lissy Jarvik, owayekade efundela isifo i-Alzheimer's. Ngakho sacabanga ngenkinga. Ngokusobala sasicabanga ukuthi isifo i-Alzheimer's sasivame kakhulu kunalokho okwakucatshangwa muntu, futhi kungcono siqale ukuba nentshisekelo kulokho okufanele sikwenze ngakho. Sitadishe okunye kokutholwe kwesayensi kokuqala okwakusanda kuphuma okwahlonza izinqubo ezithile ebuchosheni ezazihlaselwe isifo i-Alzheimer's ezazihilela ikhemikhali ebizwa ngokuthi i-Acetyl-choline. Ngakho-ke sithole indlela yokuzama ukukhulisa inani le-Acetyl-choline ebuchosheni futhi lokho kusiholela ekusebenziseni isidakamizwa esibizwa ngokuthi i-physostigmine okuyisidakamizwa esifana nezidakamizwa zamanje ezisetshenziselwa ukwelapha isifo se-Alzheimer, njenge-donepezil (Aricept) noma i-galantamine ( Razadyne), noma rivastigmine (Excelon and Excelon patch). Lowo msebenzi sawenza ngo-5-5 sawushicilela ngo-1978 kwabe kuwumqondo wokuzama ukwelapha iziguli ezinalesi sifo, kwase kufana kakhulu nokusetshenziswa kwalo muthi nalawo asetshenziswa eParkinson.
Engakubona ngokushesha ukuthi le mithi ayisivimbi isifo i-Alzheimer's ibonakala isisiza kancane, kodwa ayikuvimbi. Kudingeka sisiqonde ngempela lesi sifo ukuze sikwazi ukumisa inqubo yesifo ngokuphelele, futhi ngisakholelwa ukuthi lokho kungenzeka, futhi uma besingahamba ngendlela efanele yocwaningo ngikholelwa ukuthi singasiqeda ngokuphelele isifo i-Alzheimer's, kodwa kuzothatha ukuqonda okuthile. yokuthi inqubo iyini. Kungaleso sikhathi lapho ngangena khona ekuthuthukiseni ithiyori ye-neuroplasticity kanye nokuthi i-neuroplasticity yikho okuhlaselwa yi-Alzheimer pathology ebuchosheni. Bekunephepha nje elaphuma kuJournal elithi “Aging,” September 2014, ngomunye wabangane bami, uDale Bredesen, ophethe iBuck Institute on Aging in Northern California, futhi unephepha elinesihloko esithi “Reversal of Cognitive Decline. , Uhlelo Olusha Lokwelapha,” futhi usebenzisa inkolelo-mbono engangiyisungule emuva ngo-2002, yokuthi uma uqonda izindlela eziqondile i-Alzheimer's ehlasela ngayo ubuchopho ungashintsha izinto eziningi ezahlukene ekudleni kwakho nasezindaweni ezizungezile ezingase ziyeke. le nqubo ngokuphelele. Yilokhu esifuna ukukwenza ngempela, asifuni ukuthi abantu belashwe i-Alzheimer's, sifuna ukuthi ivinjwe. Ngiyajabula ukukhuluma nawe okwengeziwe ngalokho.
I-Lori:
Kulungile. Kulungile, lokho kuhle kakhulu, ngiyazi ukuthi i-Alzheimer's Disease International isanda kuphuma nombiko omkhulu mayelana nokunciphisa ubungozi engimaziyo u-Mart Wortman, Umqondisi Omkhulu, wayecacisa kakhulu ukuthi lesi kwakungesona isiqinisekiso. Uyazi zonke lezi zinto abakhuluma ngazo zilungele imizimba yethu iyonke kodwa kuyacaca ukuthi ngeke kube buhlungu ukukhuthala ekuqhubekiseni izinto phambili.