Iindlela eziPhezulu eziNgena-Invasive zokuHlola izifo zesibindi eziqhelekileyo ezixhaswe yi-IT & AI
Indlela yokuchonga kunye nokuvavanya i-NASH kunye ne-fibrosis efumene eyona ngqalelo ibanzi ukuza kuthi ga ngoku yi-biopsy yesibindi. Ngelishwa, bubuchwephesha obuhlaselayo, kwaye bunokufaniswa okulambathayo, ukuthambekela komjongi, kunye nomngcipheko weengxaki. Ngoko ke, uphando lwakutsha nje lugxininise ekuphandeni kovavanyo olungathinteliyo lwe-fibrosis, NAFLD, kunye ne-NASH kwizicelo zeklinikhi.
Uphando ekusebenziseni i-AI ukunyanga ukugula kwesibindi lukhulile kutshanje. I-AI kwi-hepatology ingasetyenziselwa ukuxilonga isifo sesibindi esinamafutha angasinxilisayo, ukwahlula phakathi kwezilonda ezigxininisekileyo zesibindi, ukuchonga i-fibrosis yesibindi, kwaye uqikelele ukuxilongwa kwesifo sesibindi esingapheliyo. I-AI kulindeleke ukuba inciphise iimpazamo zonyango, ibikezele iziphumo zeklinikhi, kwaye incedise ekulawuleni abaguli abanesifo sesibindi.
Eli nqaku ligxininisa izibonelelo zokukhetha indlela yokuxilonga yovavanyo lwesibindi ephuculweyo exhaswa yi-IT & AI.
Imisebenzi kunye neNzuzo yeNdlela yoHlolo lweSibindi esingaHlaseliyo kunye neeNzuzo
Ilungelo lokushicilela: Mohammed Hassan on Pixabay I License: CC0 Public Domain
Ngeephaneli ze-multi-biomarker, ukuxilongwa kwegazi kunokubeka iliso ngokuchanekileyo kunye nokuvavanya iinkqubo zebhayoloji ezenzeka esibindini. Zinokuba luncedo ekuxilongeni kokuqala kweengxaki zesibindi kuba zisebenza ngakumbi kwaye zifikeleleke kuneendlela zokucinga. Ukuchonga i-fibrosis ephucukileyo kunye noqikelelo lokuqhubeka kwayo, iimvavanyo ezithembisayo ze-biomarker zibandakanya isalathiso se-Fibrosis-4 kunye nephaneli eyongeziweyo ye-fibrosis yesibindi.
Ekuchongeni nasekugwebeni ubunzima beengxaki zesibindi, iindlela zokucinga zibonakalise ukuba zithembeke ngakumbi. Ndwendwela inkampani yetekhnoloji yezempilo ekwi-intanethi efana fibronostics.com ukufumana izisombululo eziguquguqukayo, ezingahlaseliyo kwiingxaki ezinxulumene nesibindi. Umzekelo, i-NAFLD kunye ne-NASH zinokubonwa ngokuchanekileyo nge-magnetic resonance imaging proton density fat fraction, enokwahlula ubunzima be-NASH. Kwakhona, ukucinga ngomatshini okusekelwe kwi-ultrasonic i-imaging iya ithandwa ngakumbi njengendlela ethembekileyo yokuchonga nokulinganisa i-NAFLD.
Iindlela eziPhezulu eziNgena-Invasive zokuHlola izifo zesibindi eziqhelekileyo ezixhaswe yi-IT & AI
Ngezantsi kukho iindlela ezithile ezingabonakaliyo zokuxilonga izifo zesibindi usebenzisa i-IT & AI
Uvavanyo lweFibro (FT)
Kwiimvavanyo zegazi ezininzi, i-FibroTest (eyaziwa ngokuba yiFibroSure e-USA) ifumene ukuphononongwa okukhulu. Uvavanyo lubonakaliswe ukuba lunemilinganiselo ephezulu echanekileyo kunye nengalunganga yokubona i-fibrosis ephezulu kubantu abane-hepatitis C engapheliyo. Iquka i-haptoglobin, i-bilirubin, i-GGTP, i-apolipoprotein A-1, kunye ne-2-macroglobulin.
I-biomarker ye-fibrosis yesibindi ebizwa ngokuba yi-FibroTest (FT) yaqinisekiswa ekuqaleni kwizigulane ze-hepatitis C (CHC) ezingapheliyo ngaphambi kokuba zivavanywe kubantu abanezinye izifo eziqhelekileyo zesibindi ezifana nesifo sesibindi esinxilisayo (ALD), isifo sesibindi esingapheliyo (CHB), kunye isifo sesibindi esinamafutha angasinxilisayo (NAFLD).
Uvavanyo luye lwasebenza ngokufanelekileyo ukuqikelela i-fibrosis eqhubekayo kubantu abafumana i-methotrexate ye-psoriasis kwaye ineempawu ezifanayo zokusebenza kwizigulane ezine-hepatitis B engapheliyo kunye nesifo sesibindi esinxulumene notywala.
IFibroScan
Njengovavanyo olungangeneleli, i-Fibroscan, ekwabizwa ngokuba yi-elastography yethutyana, yindlela yokuxilonga esetyenziselwa ukuvavanya imeko yesibindi sakho. I-FDA ivume ukusetyenziswa kwe-elastography yesikhashana kwi-2013 kwizigulane ezinezifo zesibindi kuba ibonakaliswe ukuba inokwethenjelwa ekufumaneni i-fibrosis ephezulu kwizigulane ezine-hepatitis C engapheliyo, i-PBC, i-hemochromatosis, i-NAFLD, kunye ne-hepatitis engapheliyo emva kwe-LT54-57.
Ngokukodwa, isebenzisa itekhnoloji ye-ultrasound ukuvavanya inqanaba le-fibrosis okanye i-scarring enokuthi iziswe kukuphazamiseka kwesibindi okanye izigulo ezahlukeneyo. I-elastography edlulayo iqhube kakuhle kakhulu ekwahluleni i-cirrhosis nokungabikho kwe-cirrhosis, ngokwe-meta-analysis, nangona yayingachanekanga kangako ekuqikeleleni amadigri amancinci e-fibrosis.
I-elastography edlulayo inokuqhutywa kwindawo yezigulane ezingalaliswayo kwaye iyakhawuleza kwaye ayinabuhlungu. Kubantu abane-cirrhosis, uvakalelo lwenkqubo kunye neenkcukacha ezithile zinokufikelela kuma-90%.
I-Acoustic Radiation Force imaging (ARFI)
Ngoncedo lweepulses ezimfutshane ze-acoustic ezisasaza amaza okucheba kwaye zibangele ukufuduka kwezicubu zendawo, i-acoustic radiation force impulse (ARFI) imaging yenza ngokufanayo kwi-elastography yexesha elifutshane. Inovakalelo kunye neenkcukacha ezingaphezulu kwe-90% ye-cirrhosis kunye ne-85% ukuya kwi-85% kwisigaba se-F2 ukuya kwi-F4 fibrosis.
Okuluncedo kobu buchule bokucinga kukuba bunokusetyenziswa kunye nesixhobo se-ultrasound esiqhelekileyo kwaye yoyisa izithintelo zexeshana ze-elastography ze-ascites kunye nokutyeba. Uphononongo lwakutsha nje lubonise ukongama kwe-imaging ye-ARFI kune-elastography yexeshana. Indawo yovavanyo yomfanekiso we-ARFI imxinwa (10 mm 6 mm) kunaleyo ye-elastography yexeshana (1 cm 4 cm).
Ukujonga umfanekiso weMagnetic Resonance (MRI)
I-MRI yenye indlela ephucukileyo yokuxilonga i-Non-Invasive. Kuye kwangqinwa ukuba ikhuselekile kwaye iyasebenza. Umqhubi we-pneumatic obekwe kumphezulu wesisu uvumela i-magnetic resonance elastography ukuchonga amaza e-chear asasazeka ngaphakathi kwesibindi usebenzisa ulandelelwano olulungisiweyo lwe-phase-contrast imaging. Imilinganiselo yokuqina kwesibindi ithathwa kwiipateni zokufuduswa kwamaza ngeefoto zemibala eyahlukeneyo.
Kwi-fibrosis enzima, ukusebenza kuphezulu kunoko elastography yexeshana. Ukukwazi ukusebenzisa le ndlela yokucinga kumatshini oqhelekileyo wokujonga i-resonance magnetic resonance ukuvavanya isibindi sonke yenye yeenzuzo zayo, nangona inkqubo inokuthatha ixesha kwaye ibiza.
Ilungelo lokushicilela: RF_Studio kwiPexels I License: CC0 Public Domain
Fumana uFundo oluSebenzayo kunye noLondolozo olungenaMngcipheko
Itekhnoloji yenze iinkqubo zokuxilongwa kwesibindi zilula kwaye zikhuselekile. Ukubekwa esweni kunye nokubeka iliso kwiziphazamiso zesibindi ezingapheliyo, iimvavanyo ezingangeneleli zenza enye indlela enyanzelisayo kwi-biopsy yesibindi. Xa i-biopsy yesibindi ayinayo inketho, ubuchule obungaxhatshaziyo obunika ulwazi olufanayo lukhetho olukhulu.