Ukunyaniseka kweMemTrax Uvavanyo lweMemori The lekiswa ne Montreal Cognitive Assessment ekuFumaneni ukukhubazeka okuPhakamileyo kwengqondo kunye ne-Dementia ngenxa yeSifo se-Alzheimer kwiQela laseTshayina

 

Xiaolei Liu, Xinjie Chen , Xianbo Zhou , Yajun Shang, Fan Xu , Junyan Zhang, Jingfang He, Feng Zhao, Bo Du, Xuan Wang, Qi Zhang, Weishan Zhang, Michael F Bergeron, Tao Ding, J Wesson Ashford, Lianmei Zhong

• PMID: 33646151
• I-DOI: 10.3233/JAD-200936

Abstract

 

imvelaphi: Ingqiqo yedijithali esebenzayo, ethembekileyo, efikelelekayo, ebandakanyayo, nefikelelekayo isixhobo sesikrini kusetyenziso lwezonyango lufuneka ngokungxamisekileyo.

 

Injongo: Ku Vavanya usetyenziso lweklinikhi yovavanyo lwenkumbulo ye-MemTrax ukuze kufunyanwe kwangoko ukonakala kwengqondo kwiqela lamaTshayina.

 

Iindlela: I-MemTrax yemizuzu eyi-2.5 kunye neMontreal Uvavanyo lokuqonda (I-MoCA) yenziwa yi-50 efunyenwe kwikliniki ngokwengqondo eqhelekileyo (CON), i-50 yokukhubazeka kwengqondo encinci ngenxa ye-AD (MCI-AD), kunye ne-50 isifo se-Alzheimer (AD) abathathi-nxaxheba bokuzithandela. Ipesenti yeempendulo ezichanekileyo (MTx-% C), ixesha elichanekileyo lokuphendula (MTx-RT), kunye namanqaku adibeneyo (MTx-Cp) we-MemTrax kunye namanqaku e-MoCA ahlalutywe ngokuthelekisayo kunye ne-receiver operating character (ROC) curves eyenziwe.

 

iziphumo: Uhlalutyo lwe-Multivariate linear regression lubonakaliswe i-MTx-% C, i-MTx-Cp, kunye ne-MoCA yamanqaku aphantsi kakhulu kwi-MCI-AD ngokuchasene ne-CON kunye ne-AD ngokuchasene namaqela e-MCI-AD (zonke ezine-p≤0.001). Ngokwahlulahlula kwe-MCI-AD ukusuka kwi-CON, i-MTx-% C cutoff ephuculweyo ye-81% ine-72% yobuntununtunu kunye ne-84% ethile kunye nommandla ongaphantsi kwe-curve (AUC) ye-0.839, ngelixa i-MoCA inqaku le-23 ine-54% ye-sensitivity. kunye ne-86% ethile ene-AUC ye-0.740. Ngokwahlulahlula kwe-AD ukusuka kwi-MCI-AD, i-MTx-Cp ye-43.0 ine-70% yobuntununtunu kunye ne-82% ecacileyo kunye ne-AUC ye-0.799, ngelixa amanqaku e-MoCA angama-20 ane-84% ye-sensitivity kunye ne-62% ecacileyo kunye ne-AUC ye-0.767.

 

Isiphelo: I-MemTrax inokubona ngokufanelekileyo zombini i-MCI kunye ne-AD efunyaniswe ekliniki ngokuchaneka okungcono xa kuthelekiswa ne-MoCA esekwe kwii-AUCs kwiqela laseTshayina. Ukunyaniseka kovavanyo lweMemTrax lweMemori lusekiwe.

 

Internet: Isifo sika-Alzheimer; isixhobo sovavanyo lwengqondo; iparadigm yomsebenzi wokwamkelwa okuqhubekayo; ukuphazamiseka kwengqondo okuphakathi.