IsiKhokelo sika-2023 ukuya kwi-Epithalon

Uphando lubonisa ukuba i-Epitalon, ehlala ibhalwe i-Epithalone, yi-analog yokwenziwa ye-Epithalamin, i-polypeptide eveliswa kwi-pineal gland. Ukuba unomdla wokufunda ngakumbi ngale peptide, qhubeka ufunda isikhokelo sika-2023 se-Epitalon peptide.

Unjingalwazi uVladimir Khavinson waseRussia wenze ukufunyanwa kokuqala kwe-Epitalon peptide kwiminyaka emininzi eyadlulayo[i]. Wazama iimpuku iminyaka engama-35 ukufunda ngakumbi malunga nomsebenzi we-Epitalon.

Uphando lubonisa ukuba umsebenzi ophambili we-Epitalon kukunyusa amanqanaba angapheliyo e-telomerase. I-Telomerase yi-endogenous enzyme eququzelela ukuphindaphinda kweselula kwe-telomeres, i-endcaps ye-DNA. Le nkqubo, nayo, ikhuthaza ukuphindaphindwa kwe-DNA, eyimfuneko ekuphuhliseni iiseli ezintsha kunye nokuhlaziywa kwezindala, njengoko kufunyenwe kuphando.

Uphando lucebisa ukuba ukuveliswa kwe-telomerase kuphezulu kwiimpuku ezincinci xa kuthelekiswa nezilwanyana ezindala. Bakwadala ii-telomeres ezinde, eziphucula impilo yeselula kunye nokuphindaphinda.

Ukuveliswa kwe-telomerase kuyehla ngokukhula kwiimpuku, nto leyo icothisa ukuphindaphindeka kweeseli. Apha kuxa i-Epitalon isiza, njengoko kubonisiwe kwizifundo zeklinikhi.

Nguwuphi umsebenzi odlalwa yi-Epitalon?

Isebenza njani iEpitalon? Uphononongo lwezilwanyana lubonise ukusebenza kwayo ekumodareyitheni isantya semetabolism, ukonyusa uvakalelo lwe-hypothalamic, ukugcina ukusebenza kwe-pituitary yangaphambili, kunye nokulawula amanqanaba e-melatonin.

Uphando lubonisa ukuba iDNA ekwinucleus yeseli nganye inemisonto emibini; kungoko isidalwa ngasinye esine-Epithalon peptide[ii] sahlukile ngokwemfuza. IiTelomeres zinokufunyanwa ekupheleni kwemisonto yeDNA. Bagcina i-DNA yolandelelwano lwengqibelelo ngokuchasa ukufinyezwa kweechromosomes ngecandelo ngalinye leseli, ngokweziphumo zeklinikhi.

Uphando lubonisa ukuba i-telomeres yeseli nganye iba mfutshane ngenxa yokuphindaphinda okungafezekanga okwenzeka rhoqo xa iiseli zihlukana. 

Izifundo ezininzi ziye zanxibelelanisa oku kunqunyulwa kwezifo ezahlukeneyo ezinxulumene nobudala, kubandakanya nesifo sentliziyo kunye nokufa kwangaphambi kwexesha kwiimpuku.

Ngokutsho kweziphumo zophando, i-concentration ephezulu ye-Epitalon ibizwa ngokuba "ngumthombo wobutsha" ngenxa yempembelelo yayo enhle kwimpilo kunye nobomi.

Iziphumo zokuSebenzisa i-Epitalon

I-Epitalon yikhemikhali ethi, ngokwezifundo ezininzi[iii] ezenziwa kwizilwanyana kunye neempuku, i-physiologically ifana naleyo yenziwa ngumzimba wempuku. Le nkqubo ibuyisela iwashi yebhayoloji yeselula, ivumela izicubu ezonakalisiweyo ukuba ziphilise kwaye zibuyisele ukusebenza kwelungu eliqhelekileyo.

Kwiminyaka emininzi edlulileyo, izazinzulu zaseRashiya ziye zafumanisa izinto ezininzi ezinxulumene ne-Epithalon. Ngokomzekelo, izazinzulu ziye zafumanisa ukuba inokuvuselela ukuveliswa kweeseli ze<em>telomerase. Ukongeza, bayaqonda ukuba inokuvuselela umzimba wonke kwaye iphucule impilo. Bafumanise ukuba iyakwazi ukubuyisela umva ukuguga ngokujolisa unobangela wayo kwizifundo zophando.

Izinto eziluncedo ze-Epitalon Peptide

Uphononongo lubonisa ukuba i-Epitalon ineenzuzo ezininzi. Iinzuzo ezilungileyo kwimpilo eziye zabonwa kwizifundo zezilwanyana kusetyenziswa i-Epitalon peptide zezi zilandelayo:

  • Yandisa ixesha lokuphila kweempuku.
  • Inceda ukugcina izilwanyana zingenazo iimeko eziwohlokayo, kuquka i-Alzheimer's, isifo sentliziyo kunye nomhlaza
  • Yandisa umgangatho wokulala.
  • Ukuphucula impilo yolusu
  • Iimpembelelo kukuqina kweeseli zezihlunu
  • Yandisa izinga lokubuyisela
  • Ukunciphisa i-lipid peroxidation kunye nokuveliswa kwe-ROS
  • Ukuphakamisa umda woxinzelelo lweemvakalelo
  • Igcina izixa ezizinzileyo zemelatonin kwiimpuku

Uphononongo oluninzi lwale proteni luyafuneka ukuze ufunde iziphumo zayo ezipheleleyo. Ukususela oko abaphandi baye bafunda nge-Epithalon, nangona kunjalo, kubonakala ngathi iya kufumaneka ngokukhawuleza ukunyanga nokunyanga iingxaki ezininzi zempilo. Ngokumangalisayo, abaphandi banethemba elikhulu lokubakho kwe-Epitalon njengonyango lomhlaza kunye nothintelo.

Apha, siza kujonga ukusebenza kwe-Epitalon peptide kunye nokusetyenziswa kwayo kwiinkcukacha ezithe vetshe ukuze uthathe isigqibo sokuba uyibandakanye na kwizifundo zakho zophando.

IiPropati eziSebenzayo zokuLwa nokuguga kwe-Epitalon

I-Biopeptide Epitalon yaboniswa ukwandisa ubomi beegundane nge-25% kwisifundo esibizwa ngokuthi "I-neuroendocrine theory of aging and degenerative disease," ebhalwe nguProfesa Vladimir Dilmice kunye noDkt Ward Dean kwi-1992.

Uphando olulandelelweyo oluninzi nguMongameli iSt. Petersburg Institute of Bio-regulation kunye noProfesa Vladimir Khavinson waqinisekisa ezi ziphumo zokuqala.

Umthamo we-Epitalon wokwenza uqhagamshelo lwe-peptide phakathi kwee-amino acids ezininzi, njengoko zifunyenwe zezi nzululwazi, zinegalelo kwiziphumo zokwandisa ixesha elide lekhompawundi. Ngokweziphumo zophando, inokuthintela ukukhula kwethumba kunye nokwandisa umsebenzi wobuchopho.

U-Khavinson ufumene, kwiimpuku, ukuba i-biopeptides iphucule ngokumangalisayo ukusebenza kwengqondo kwaye yehlisa ukufa kwabantu phantse ngama-50% emva kweminyaka eli-15 yokujongwa kwezonyango.

Uye wanikezela ngobungqina bokuba intsebenziswano phakathi kwe-Epithalon biopeptides kunye ne-DNA inokulawula imisebenzi ebalulekileyo yemfuza, ukwandisa ngokufanelekileyo ubomi.

Uphononongo lubonisa ukuba i-Epitalon yandisa ubomi beempuku xa kuthelekiswa nezilwanyana eziphathwe nge-placebo ukusuka kwinyanga ezintathu ukuya kutsho ekufeni. Ngokweziphumo zophononongo, i-chromosomal aberrations kwiiseli zomongo wethambo ngokufanayo zancitshiswa emva konyango nge-Epitalon. Iimpuku eziphathwe nge-Epitalon nazo azibonakalisi zimpawu zokuphuhlisa i-leukemia. Iziphumo zophononongo, ezithathwe xa zizonke, zibonisa ukuba le peptide ineempembelelo ezichasene nokuguga kwaye inokusetyenziswa ngokukhuselekileyo ngokungenasiphelo.

Izifundo ezininzi zezilwanyana ziqinisekisa ezi ziphumo zilandelayo ze-Epitalon:

  • I-Cortisol kunye ne-melatonin synthesis iyacotha ngokukhula kweenkawu, enceda ukugcina isingqi se-cortisol esizinzileyo.
  • Inkqubo yokuzala yeempuku yayikhuselwe ekwenzakaleni, yaye izithintelo zalungiswa.
  • Isakhiwo se-retina sihlala sinjalo nangona isifo siqhubela phambili kwi-retinitis pigmentosa.
  • Iimpuku ezinomhlaza wekholoni ziye zehla ukukhula.

Impembelelo kuLusu 

Izifundo zezilwanyana ziye zabonisa ukuba ukongeza kwiipropathi zayo zokulwa nokuguga, i-Epitalon iphucula impilo yesikhumba.

Ngokutsho kophando lukaDkt. Khavinson, i-Epithalon inokuvuselela iiseli[iv] ezijongene nokulungisa nokugcina i-matrix engaphandle egcina ulusu lusempilweni kwaye luncinci. I-Collagen kunye ne-elastin zi-superstars ezimbini ezichasene nokuguga kwi-matrix engaphandle.

Uphononongo lubonisa ukuba i-lotions ezininzi zokulwa nokuguga zithembisa ukuqinisa i-collagen eluswini, kodwa yi-Epitalon kuphela eyenza oko. I-Epithalon ingena kwiiseli kwaye ivuselela ukwanda kunye nokuvuthwa kwe-fibroblasts ejongene nokuvelisa i-collagen kunye nezinye iiprotheni. Ngenxa yoko, oku kukhuthaza ukuvuselelwa kwesikhumba okunempilo, ngokweziphumo zophando.

Iimvavanyo zibonisa ukuba, nangona kunjalo, i-Epithalon peptide iyasebenza ngokuchasene nemiphumo yokuguga ngaphaya koko kuhlangana neso. Izifo, usulelo, kunye nokwenzakala zizinto zonke enokuzikhusela kuzo. Ulusu oludala loma, lubuthathaka, kwaye luthande ukukrazuka. Njengoko ulingo lwezonyango lubonisa, ukusebenzisa i-Epitalon eluswini kunokuthintela iziphumo ezibi.

Unyango lwe-Retinitis Pigmentosa 

Iinduku ezikwiretina zitshatyalaliswa sisifo esiwohlokayo esaziwa ngokuba yiretinitis pigmentosa. Xa ukukhanya kubetha iretina, kubangela ukukhululwa kwemiyalezo yemichiza ngeerodi. I-Epitalon iboniswe ukunciphisa umonakalo ophazamisayo kwi-retina obangelwa ukuphazamiseka kuphando lweklinikhi.

I-Epitalon iphucula ukusebenza kwe-retinal kuvavanyo lwe-rodent ngokumisa ukuwohloka kweeseli kunye nokugcina ubume beentonga, ngokwezifundo zophando.

Uphando lucebisa ukuba i-Epitalon lunyango oluyimpumelelo lwe-retinitis pigmentosa kuphando olubandakanya iimpuku kunye neempuku. Nangona kunjalo, uphando olongezelelweyo luyafuneka ukuqinisekisa ezi ziphumo. Apha unako thenga iipeptides kwi-intanethi.

[i] Anisimov, Vladimir N., kunye noVladimir Kh. Khavinson. "I-Peptide Bioregulation yokuguga: Iziphumo kunye neProspects." I-Biogerontology 11, no. 2 (Oktobha 15, 2009): 139-149. doi:10.1007/s10522-009-9249-8.

[ii] Frolov, DS, DA Sibarov, kunye no-AB Vol'nova. "UMbane oTshintshiweyo ozenzekelayo ofunyenwe kwi-Rat Motor Neocortex emva kwe-Intranasal Epitalon Infusions." I-PsycEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). I-AEDG Peptide (i-Epitalon) Ivuselela i-Gene Expression kunye ne-Protein Synthesis ngexesha le-Neurogenesis: I-Epigenetic Mechanism enokwenzeka. Iimolekyuli, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, NI, NS Linkova, AN Zhekalov, AO Orlova, GA Ryzhak, kunye noV. Kh. Khavinson. "IiPeptides ezimfutshane zivuselela ukuHlaziywa kweeSeli kuLusu ngexesha lokuguga." Ukuqhubela phambili kwiGerontology 5, no. 3 (Julayi 2015): 176-179. doi: 10.1134 / s2079057015030054.

[v] Korkushko, OV, V. Kh. Khavinson, VB Shatilo, kunye noLV Magdich. "Impembelelo ye-Peptide yokuLungisa i-Epithalamin kwi-Circadian Rhythm ye-Epiphyseal Melatonin-Ukuvelisa Umsebenzi kubantu abaDala." I-Bulletin ye-Biology yoMfuniselo kunye neMithi ye-137, no. 4 (Aprili 2004): 389-391. doi:10.1023/b:bebm.0000035139.31138.bf.

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