Jagoran 2023 Zuwa Epithalon

Bincike ya nuna cewa Epitalon, sau da yawa ana rubuta Epithalone, shine analog na roba na Epithalamin, polypeptide da aka samar a cikin glandar pineal. Idan kuna sha'awar ƙarin koyo game da wannan peptide, ci gaba da karanta jagorar 2023 zuwa Epitalon peptide.

Farfesa Vladimir Khavinson na Rasha ya fara gano Epitalon peptide shekaru da yawa da suka wuce[i]. Ya yi gwaji a kan beraye na tsawon shekaru 35 don ƙarin koyo game da aikin Epitalon.

Bincike ya nuna cewa aikin farko na Epitalon shine haɓaka matakan telomerase na ƙarshe. Telomerase wani enzyme ne na endogenous wanda ke sauƙaƙe kwafin telomeres na salula, ƙarshen DNA. Wannan tsari kuma yana ƙarfafa kwafin DNA, wanda ya zama dole don haɓaka sabbin ƙwayoyin cuta da sabunta tsofaffi, kamar yadda binciken binciken ya nuna.

Bincike ya nuna cewa samar da telomerase ya fi girma a cikin ƙananan beraye idan aka kwatanta da tsofaffin dabbobi. Hakanan suna haifar da telomeres masu tsayi, waɗanda ke inganta lafiyar salula da kwafi.

Samar da telomerase yana raguwa tare da shekaru a cikin berayen, wanda ke rage saurin haɓaka tantanin halitta. Anan ne lokacin da Epitalon ya zo da amfani, kamar yadda binciken asibiti ya nuna.

Wane aiki Epitalon ke takawa?

Ta yaya Epitalon ke aiki? Nazarin dabba ya nuna ingancinsa a cikin daidaita yanayin rayuwa, haɓaka haɓakar hypothalamic, kiyaye aikin pituitary na baya, da sarrafa matakan melatonin.

Bincike ya nuna cewa DNA a cikin tsakiya na kowane tantanin halitta yana da nau'i biyu; Don haka kowace halitta mai Epithalon peptide [ii] ta bambanta ta asali. Ana iya samun Telomeres a ƙarshen sassan DNA. Suna kiyaye mutuncin jerin DNA ta hanyar magance gajarta chromosomes tare da kowane sashin tantanin halitta, kamar yadda binciken asibiti.

Bincike yana nuna cewa telomere na kowane tantanin halitta ya zama guntu saboda rashin kwafi da ke faruwa a duk lokacin da sel suka rabu. 

Yawancin bincike sun danganta wannan gajarta ga cututtuka daban-daban masu alaƙa da shekaru, gami da cututtukan zuciya da jijiyoyin jini da ma mutuwa da wuri a cikin beraye.

Bisa ga binciken bincike, an kira babban taro na Epitalon "maɓuɓɓugar matasa" saboda tasiri mai kyau ga lafiya da tsawon rayuwa.

Sakamakon Amfani da Epitalon

Epitalon wani sinadari ne wanda, bisa ga bincike da yawa[iii] da aka yi akan dabbobi da beraye, a fannin ilimin halittar jiki yayi kama da wanda jikin linzamin kwamfuta ke samarwa. Wannan tsari yana sake saita agogon nazarin halittu na salula, yana barin kyallen jikin da suka lalace su warke da dawo da aikin gabobin jiki na yau da kullun.

A cikin shekaru da yawa da suka gabata, masana kimiyya a Rasha sun yi bincike da yawa game da Epithalon. Misali, masana kimiyya sun gano cewa zai iya farfado da samar da telomerase ta salula. Bugu da ƙari, sun fahimci cewa yana iya farfado da jiki gaba ɗaya kuma ya inganta lafiya. Sun gano cewa yana iya ma kawar da tsufa ta hanyar yin niyya ga tushen sa a cikin binciken bincike.

Amfanin Epitalon Peptide

Nazarin ya nuna cewa Epitalon yana da fa'idodi da yawa. Kyakkyawan fa'idodin kiwon lafiya waɗanda aka gani a cikin nazarin dabbobi ta amfani da Epitalon peptide sune kamar haka:

• Yana ƙara tsawon rayuwar beraye.
• Yana taimakawa kare dabbobi daga yanayin lalacewa, gami da Alzheimer's, cututtukan zuciya, da kansa
• Yana ƙara ingancin barci.
• Inganta lafiyar fata
• Tasiri akan ƙarfin ƙwayar tsoka
• Yana ƙara yawan dawowa
• Yana rage peroxidation lipid da samar da ROS
• Ƙarfafa ƙofa don damuwa na motsin rai
• Yana kiyaye adadin melatonin a cikin mice

Ana buƙatar ƙarin nazarin wannan furotin don koyon cikakken tasirinsa. Daga abin da masu bincike suka koya game da Epithalon, duk da haka, da alama cewa nan ba da jimawa ba za a iya samun damar yin magani da kuma magance matsalolin kiwon lafiya da yawa. Abin mamaki, masu bincike suna da babban bege ga yuwuwar Epitalon a matsayin maganin cutar kansa da rigakafin.

Anan, zamu bincika ingancin Epitalon peptide da amfanin daki-daki domin ku yanke shawarar ko zaku saka shi a cikin binciken bincikenku.

Ingantattun Kayayyakin Anti-Aging na Epitalon

An nuna Biopeptide Epitalon ya kara tsawon rayuwar berayen da kashi 25 cikin dari a wani bincike mai suna "The neuroendocrine theory of tsufa da rashin lafiya," wanda Farfesa Vladimir Dilmice da Dr. Ward Dean suka rubuta a 1992.

Bincike da yawa na bin diddigin da Shugaban Cibiyar Nazarin Halittu ta St. Petersburg da Farfesa Vladimir Khavinson suka yi sun tabbatar da waɗannan sakamakon farko.

Ƙarfin Epitalon don samar da haɗin gwiwar peptide tsakanin yawancin amino acid, kamar yadda waɗannan masana kimiyya suka samo, yana ba da gudummawa ga tasirin daɗaɗɗen ginin. Dangane da binciken bincike, yana iya hana ci gaban ƙari da haɓaka ayyukan ƙwaƙwalwa.

Khavinson ya gano, a cikin berayen, cewa biopeptides ya inganta aikin ilimin lissafi sosai kuma ya rage yawan mace-mace da kusan 50% bayan shekaru 15 na kulawar asibiti.

Ya kuma ba da shaida cewa hulɗar tsakanin Epithalon biopeptides da DNA na iya daidaita mahimman ayyukan kwayoyin halitta, da tsawaita tsawon rayuwa yadda ya kamata.

Nazarin ya nuna cewa Epitalon ya tsawaita rayuwar beraye idan aka kwatanta da dabbobin da aka yi wa maganin placebo tun daga shekara ta watanni uku har zuwa mutuwa. Dangane da sakamakon binciken, chromosomal aberrations a cikin ƙwayoyin kasusuwa na kasusuwa an rage haka nan bayan jiyya tare da Epitalon. Mice da aka yi da Epitalon kuma ba su nuna alamun tasowa cutar sankarar bargo ba. Sakamakon binciken, wanda aka ɗauka gabaɗaya, ya nuna cewa wannan peptide yana da tasiri mai mahimmanci na rigakafin tsufa kuma ana iya amfani dashi cikin aminci har abada.

Yawancin binciken dabba sun tabbatar da sakamako masu zuwa na Epitalon:

• Haɗin cortisol da melatonin yana raguwa tare da shekaru a cikin birai, wanda ke taimakawa wajen tabbatar da tsayayyen hawan cortisol.
• An kiyaye tsarin haihuwa na beraye daga cutarwa, kuma an gyara nakasu.
• Tsarin ido ya kasance cikakke duk da ci gaban cutar a cikin retinitis pigmentosa.
• Beraye masu ciwon daji na hanji sun sami raguwar girma.

Tasiri akan Fata 

Nazarin dabbobi ya nuna cewa baya ga maganin tsufa, Epitalon yana inganta lafiyar fata.

A cewar binciken Dr. Khavinson, Epithalon na iya tada sel [iv] da ke kula da gyara da kuma kula da matrix na waje wanda ke kula da lafiyar fata da matasa. Collagen da elastin su ne manyan taurarin anti-tsufa biyu a cikin matrix extracellular.

Nazarin ya nuna cewa mayukan hana tsufa da yawa sun yi alƙawarin ƙarfafa collagen a cikin fata, amma Epitalon ne kawai ke yin haka. Epithalon yana shiga cikin sel kuma yana haɓaka haɓakawa da haɓakar fibroblasts waɗanda ke da alhakin samar da collagen da sauran sunadaran. Sakamakon haka, wannan yana inganta sabunta fata lafiya, bisa ga binciken bincike.

Gwaje-gwaje sun nuna cewa, duk da haka, Epithalon peptide yana da tasiri a kan tasirin tsufa fiye da abin da ya hadu da ido. Cuta, kamuwa da cuta, da rauni duk abubuwan da zai iya kare su. Tsohuwar fata ta zama bushewa, mai rauni, kuma ta fi saurin tsagewa. Kamar yadda gwaje-gwajen asibiti suka nuna, yin amfani da Epitalon a fata na iya hana irin wannan illa.

Maganin Retinitis Pigmentosa 

An lalata sanduna a cikin ido ta hanyar rashin lafiya mai lalacewa da aka sani da retinitis pigmentosa. Lokacin da haske ya kama kwayar ido, yana haifar da sakin sakonnin sinadarai ta hanyar sanduna. An nuna Epitalon don rage lalacewa na lalacewa ga retina da cutar ta haifar a cikin binciken asibiti.

Epitalon yana inganta aikin gani na ido a cikin gwaje-gwajen rodent ta hanyar dakatar da lalata tantanin halitta da kiyaye tsarin sanda, kamar yadda binciken bincike ya nuna.

Bincike ya nuna cewa Epitalon nasara ce ta maganin retinitis pigmentosa a cikin binciken da ya shafi beraye da beraye. Koyaya, ana buƙatar ƙarin bincike don tabbatar da waɗannan sakamakon. Anan zaka iya saya peptides akan layi.

[i] Anisimov, Vladimir N., da Vladimir Kh. Khavinson. "Peptide Bioregulation na tsufa: Sakamako da Al'amura." Biogerontology 11, no. 2 (15 ga Oktoba, 2009): 139–149. doi:10.1007/s10522-009-9249-8.

[ii] Frolov, DS, DA Sibarov, and AB Vol'nova. "An Gano Canza Ayyukan Wutar Lantarki na Kwatsam a cikin Motar Neocortex na Rat bayan Jikin Epitalon na Intranasal." PsycEXTRA Dataset (2004). doi:10.1037/e516032012-081.

[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). AEDG Peptide (Epitalon) Yana Ƙarfafa Bayyanar Halittar Halittar Halittar Halittar Halittar Halittar Halitta da Ƙwararrun Protein a lokacin Neurogenesis: Ƙimar Epigenetic Mechanism. Molecules, 25(3), 609. doi:10.3390/molecules25030609

[iv] Chalisova, NI, NS Linkova, AN Zhekalov, AO Orlova, GA Ryzhak, da V. Kh. Khavinson. "Gajeren Peptides Yana Ƙarfafa Farfaɗowar Kwayoyin Halitta a Fatar Lokacin Tsufa." Ci gaba a Gerontology 5, No. 3 (Yuli 2015): 176-179. Doi: 10.1134 / s2079057015030054.

[v] Korkushko, OV, V. Kh. Khavinson, VB Shatilo, da kuma LV Magdich. "Tasirin Shirye-shiryen Peptide Epithalamin akan Circadian Rhythm na Ayyukan Samar da Epiphyseal Melatonin a cikin Manya." Bulletin na Kwayoyin Gwaji da Magunguna 137, No. 4 (Afrilu 2004): 389-391. doi:10.1023/b:bebm.0000035139.31138.bf.