ỌRỊA ALZHEIMER: NDỊ NEURON Plasticity ọ̀ na-ebute ụzọ na-aga n'ihu AXONAL NEUROFIBRILLARY DEGENERATION?
Akwụkwọ akụkọ ọgwụ nke New England, Vol. 313, peeji nke 388-389, 1985
ỌRỊA ALZHEIMER: NDỤMỌDỤ NEURON ọ̀ na-ebuli elu na AXONAL NEUROFIBRILLARY DEGENERATION?
Nye onye nchịkọta akụkọ: Gajdusek na-eche na nkwụsị nke neurofilaments bụ ihe ndabere maka ọtụtụ ọrịa dementing ( mbipụta March 14). 1 Iji kọwaa ihe kpatara na ụfọdụ neurons na ụbụrụ na-emetụta ma ọ bụghị ndị ọzọ, ọ na-atụ aro na mkpụrụ ndụ ndị nwere nnukwu osisi axonal, n'ihi nnukwu ihe ha na-achọ maka njem axonal, na-enwekarị nsogbu na mmebi axoskeletal. Echiche Gajduseks mara mma mana Ọ naghị aza ajụjụ maka nleba anya na nnukwu neurons otor na-emetụta obere ihe na ọrịa Alzheimer.
Anyị na-atụ aro na plasticity cell yana oke osisi axonal nwere ike ịmanye ihe a chọrọ na njem axonal. A na-ejikọta plasticity nke mkpụrụ ndụ neural na ihe dị iche iche nke trophic,2 ụfọdụ n'ime ha gụnyere njem axonal. Otu ihe atụ dị mkpa bụ ome nke a na-ahụ na njedebe septal norepinephrine,3 enwere ike na-esonyere ya na nnukwu mbubata nke neurofilaments ọhụrụ.
Neurons na-egosi ọkwa dị elu nke plasticity nwere ike ịbụ mkpụrụ nke ebe nchekwa na mmụta; Ha abụọ na-arịa ọrịa Alzheimer. Ejikọtara ụzọ norepinephrine na mmụta metụtara ụgwọ ọrụ, 4 na sel norephinephrine nke locus ceruleus na-ebibi n'ọnọdụ ụfọdụ. Ọrịa Alzheimer.5 Alzheimer degeneration na-emebikwa ebe mmalite nke mkpụrụ ndụ serotonin dị n'etiti ụbụrụ raphe,6 na serotonin ka akwadoro dị ka onye ogbugbo nke oyi oyi.7 Acetylcholine pathways projecting from the nucleus basalis of Meynert to the cortex nwere ike ịrụ ọrụ ya. nke latchkey na mgbagwoju anya ebe nchekwa nchekwa na mweghachi,8.9 na dị ka a maara nke ọma, ọrịa Alzheimer na-ejikọta ya na ọnwụ nke cell ndị a yana enzymes ha.10 N'ọkwa cortical ọkwa Alzheimer ụdị mmebi nke ọma na-emetụta neuron na mpaghara ndị na-akpakọrịta, nke kachasị mma na hippocampus na amygdala. 11 nke abụọ na-ekere òkè dị ukwuu na ebe nchekwa.12 Ọzọkwa, neurofibrillary degeneration na-apụta nke ọma na neurons na axon na-ejikọta hippocampus na cortex entorhinal.13 Ebe ọ bụ na neurons sitere na nke ọ bụla n'ime otu ndị a na-emepụta njikọ jikọtara na ntinye nke ozi,14 nke chọrọ a. ogo dị elu nke plasticity, mmebi ha na-akwado nkwubi okwu na mkpụrụ ndụ ndị na-egosi nnukwu plastik na-adịkarị mfe imebi neurofibrillary.
Nkwụsị nke usoro axonal-transport ngwa ngwa na neurons nwere ogo dị elu nke plastik nwere ike iduga nhụsianya ebe nchekwa zuru oke, isi ihe mgbaàmà nke dementia n'agbanyeghị ihe kpatara ya. Nrụ ọrụ axonal-filament a nwere ike inye ntọala micropathological maka njikọ ekesara na mbụ n'etiti microtubular diathesis na ụdị Alzheimer. dementia 15,16 wee kekọta ọnụ ngalaba nke ọrịa dementia.
J. Wesson Ashford, MD, Ph.D.
Lissy Jarvik, MD, Ph.D.
Ụlọ ọrụ Neuropsychiatric UCLA
Los Angeles, CA 90024