Hoʻopili ʻokoʻa nā ʻano hana leʻaleʻa i ka wā leʻaleʻa me ka dementia kumu a pau me ka nānā ʻole i ka hana kino.
Hoʻopili ʻokoʻa nā ʻano hana leʻaleʻa i ka wā leʻaleʻa me ka dementia kumu a pau me ka nānā ʻole i ka hana kino.
David A. Raichlen, Yann C. Klimentidis, M. Katherine Sayre, Pradyumna K. Bharadwaj, Mark HC Lai, Rand R. Wilcox, a me Gene E. Alexander
Georgia Institute of Technology, Atlanta, GA
Augate 22, 2022
119 (35) e2206931119
Vol. 119 | Helu 35
He mea nui
ʻO nā ʻano noho maʻamau (SBs), e like me ka nānā ʻana i ke kīwī (TV) a i ʻole ka hoʻohana ʻana i ke kamepiula, e lawe i kahi hapa nui o ka manawa hoʻomaha kanaka makua a pili i ka hoʻonui ʻia. pilikia o ka ma'i mau a me ka make. Ke noiʻi nei mākou inā pili nā SB me nāke kumu o ka dementia ka mea ole physical ha awina (PA). Ma kēia noiʻi cohort prospective e hoʻohana ana i ka ʻikepili mai ka UK Biobank, pili nā kiʻekiʻe kiʻekiʻe o ka cognitively passive SB (TV) me ka piʻi ʻana o ka dementia, aʻo nā kiʻekiʻe kiʻekiʻe o ka cognitively active SB (kamepiula) i pili me ka hōʻemi o ka pilikia dementia. Ua paʻa kēia mau pilina me ka nānā ʻole i nā pae PA. Hoemi ana ka nānā ʻana i ka TV cognitively passive a me ka hoʻonui ʻana i ka hana cognitively Ke hoʻohiki nei ʻo SB i nā pahuhopu no ka hōʻemi ʻana i ka maʻi neurodegenerative me ka ʻole o nā pae o ka hoʻopili ʻana o PA.
Hōʻuluʻulu Manaʻo
Hoʻopili ʻia ke ʻano sedentary (SB) me ka maʻi cardiometabolic a me ka make, akā ʻaʻole maopopo ka pili ʻana me ka dementia i kēia manawa. Ke noiʻi nei kēia haʻawina inā pili ʻo SB me ka dementia i hana ʻia me ka nānā ʻole ʻana i ka hana kino (PA). He 146,651 mau mea komo mai ka UK Biobank he 60 mau makahiki a ʻoi aʻe a ʻaʻohe hōʻoia o ka dementia (mean [SD] makahiki: 64.59 [2.84] makahiki). Ua hoʻokaʻawale ʻia nā SB manawa leʻaleʻa i hōʻike ʻia iā lākou iho i ʻelua mau kikowaena: ka manawa e nānā ai i ke kīwī (TV) a i ʻole ka manawa i hoʻohana ʻia i ke kamepiula. He 3,507 ka nui o na kanaka i loaa i kakumu o ka dementia ma luna o ka mean follow-up o 11.87 (± 1.17) makahiki. I nā hiʻohiʻona i hoʻoponopono ʻia no ka nui o nā covariates, me ka manawa i hoʻohana ʻia ma PA, ua pili ka manawa i ka nānā ʻana i ka TV me ka piʻi nui ʻana o ka dementia (HR [95% CI] = 1.24 [1.15 a i 1.32]) a ʻo ka manawa i hoʻohana ʻia i ka kamepiula. pili me ka emi o ka pilikia o ka dementia hanana (HR [95% CI] = 0.85 [0.81 i ka 0.90]). Ma nā hui pū me PA, ua pili nui ka manawa TV a me ka manawa kamepiula pilikia dementia ma nā pae PA a pau. ʻO ka hoʻemi ʻana i ka manawa i hoʻohana ʻia ma ka cognitively passive SB (ʻo ia hoʻi, ka manawa TV) a me ka hoʻonui ʻana i ka manawa i hoʻohana ʻia i ka cognitively active SB (ʻo ia hoʻi, ka manawa kamepiula) hiki ke lilo i mau pahuhopu hoʻololi kūpono no ka hōʻemi ʻana i ka pilikia o ka dementia no ka ka lolo me ka nānā ʻole i ke komo ʻana i PA.
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